Orientation and community size dependences of pulsatile electrical field stimulation on lined-up and rod-shaped single cardiomyocytes

Tomoyuki Kaneko, Fumimasa Nomura, Kenji Yasuda

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

We have examined the orientation dependence of minimum electric field intensity for the stimulation of cardiomyocytes, which were cultivated in agarose chambers, using a lined-up cardiomyocyte network with different numbers of cells and orientations. When the cell network was arranged parallel to the electric field, the required minimum electric field intensity decreased to one-fourth as cell number increased, whereas that of the cell network arranged orthogonal to the electrical field did not decrease and was independent of cell number. The required electrical field intensity of the 100 μrn rod-shaped single cardiomyocyte in a microchamber arranged parallel to the electric field was also 40% lower than that of the cell network arranged orthogonal to the electric field. The results indicate that the gradient of the electric field potential between two ends of the cell network or rod-shaped single cell is important for their excitation.

Original languageEnglish
Article number080220
JournalJapanese Journal of Applied Physics
Volume50
Issue number8 PART 1
DOIs
Publication statusPublished - 2011 Aug
Externally publishedYes

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stimulation
rods
Electric fields
cells
electric fields
chambers
gradients
excitation

ASJC Scopus subject areas

  • Engineering(all)
  • Physics and Astronomy(all)

Cite this

Orientation and community size dependences of pulsatile electrical field stimulation on lined-up and rod-shaped single cardiomyocytes. / Kaneko, Tomoyuki; Nomura, Fumimasa; Yasuda, Kenji.

In: Japanese Journal of Applied Physics, Vol. 50, No. 8 PART 1, 080220, 08.2011.

Research output: Contribution to journalArticle

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