Oriented fixation of synthetic heme complexes in phospholipid bilayer membranes: Electrooptical measurement

Makoto Yuasa, Hiroyuki Nishide, Eishun Tsuchida, Akihiko Yamagishi

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Orientation of modified porphinatoiron (heme) complexes in a phospholipid bilayer was studied by electric birefringence and dichroism. The orientation angle (φ) between the heme plane and the phospholipid bilayer is close to zero for [5α,10α,15α,20α-tetrakis(o-(2,2-dimethyl-20-(((2- (trimethylammonio)ethyl)phosphonato)oxy)eicosanamido)phenyl)porphinato]iron (1) and [5α,10α,15α,20α-tetrakis(o-(2)2-dimethyl-20-(((2- carboxypropanyl)carbonyl)oxy)eicosanamido)-phenyl)porphinato]iron (2), while it is ca. 20-30° for [5α,10α,15α,20α-tetrakis(o-pivalamidophenyl)porphinato] iron (3). The stereostructure and the hydrophilic-hydrophobic balance of 1 and 2 are assumed to emphasize compatibility and orientation of the heme in the phospholipid bilayer. 2 is copolymerized with a polymerizable phospholipid (4) in a bilayer state and is covalently and orientedly fixed in the bilayer membrane.

Original languageEnglish
Pages (from-to)2987-2990
Number of pages4
JournalJournal of Physical Chemistry
Volume92
Issue number10
Publication statusPublished - 1988

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Phospholipids
Heme
membranes
Membranes
iron
Iron
compatibility
dichroism
birefringence
Dichroism
Birefringence

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry

Cite this

Oriented fixation of synthetic heme complexes in phospholipid bilayer membranes : Electrooptical measurement. / Yuasa, Makoto; Nishide, Hiroyuki; Tsuchida, Eishun; Yamagishi, Akihiko.

In: Journal of Physical Chemistry, Vol. 92, No. 10, 1988, p. 2987-2990.

Research output: Contribution to journalArticle

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AU - Tsuchida, Eishun

AU - Yamagishi, Akihiko

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N2 - Orientation of modified porphinatoiron (heme) complexes in a phospholipid bilayer was studied by electric birefringence and dichroism. The orientation angle (φ) between the heme plane and the phospholipid bilayer is close to zero for [5α,10α,15α,20α-tetrakis(o-(2,2-dimethyl-20-(((2- (trimethylammonio)ethyl)phosphonato)oxy)eicosanamido)phenyl)porphinato]iron (1) and [5α,10α,15α,20α-tetrakis(o-(2)2-dimethyl-20-(((2- carboxypropanyl)carbonyl)oxy)eicosanamido)-phenyl)porphinato]iron (2), while it is ca. 20-30° for [5α,10α,15α,20α-tetrakis(o-pivalamidophenyl)porphinato] iron (3). The stereostructure and the hydrophilic-hydrophobic balance of 1 and 2 are assumed to emphasize compatibility and orientation of the heme in the phospholipid bilayer. 2 is copolymerized with a polymerizable phospholipid (4) in a bilayer state and is covalently and orientedly fixed in the bilayer membrane.

AB - Orientation of modified porphinatoiron (heme) complexes in a phospholipid bilayer was studied by electric birefringence and dichroism. The orientation angle (φ) between the heme plane and the phospholipid bilayer is close to zero for [5α,10α,15α,20α-tetrakis(o-(2,2-dimethyl-20-(((2- (trimethylammonio)ethyl)phosphonato)oxy)eicosanamido)phenyl)porphinato]iron (1) and [5α,10α,15α,20α-tetrakis(o-(2)2-dimethyl-20-(((2- carboxypropanyl)carbonyl)oxy)eicosanamido)-phenyl)porphinato]iron (2), while it is ca. 20-30° for [5α,10α,15α,20α-tetrakis(o-pivalamidophenyl)porphinato] iron (3). The stereostructure and the hydrophilic-hydrophobic balance of 1 and 2 are assumed to emphasize compatibility and orientation of the heme in the phospholipid bilayer. 2 is copolymerized with a polymerizable phospholipid (4) in a bilayer state and is covalently and orientedly fixed in the bilayer membrane.

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