Oscillator for self-assembled DNA nanomachines

Masahiro Takinoue, Daisuke Kiga, Koh Ichiroh Shohda, Akira Suyama

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Self-assembled DNA nanomachines have been energetically developed recently. We have invented an RNA-oscillator constructed with an autonomous biomolecular computing system in order to operate periodically DNA nanomachines driven by DNA/RNA hybridization. The biomolecular computing system, which we have developed, can convert RNA sequences from input strand to output strand by nucleic-acids hybridizations and enzymatic reactions at a constant temperature. A feedback network of the autonomous biomolecular computing system can oscillate. In this study, we simulated behaviors of the oscillator before in vitro experiments by describing each reaction step using simultaneous nonlinear differential equations. As the result of numerical simulation, we found that there were some conditions on which RNA concentrations could oscillate and the conditions depended on the balance between RNA production and degradation rates.

Original languageEnglish
Title of host publication4th Conference on Foundations of Nanoscience: Self-Assembled Architectures and Devices, FNANO 2007
Pages104-106
Number of pages3
Publication statusPublished - 2007
Externally publishedYes
Event4th Conference on Foundations of Nanoscience: Self-Assembled Architectures and Devices, FNANO 2007 - Snowbird, UT, United States
Duration: 2007 Apr 182007 Apr 21

Other

Other4th Conference on Foundations of Nanoscience: Self-Assembled Architectures and Devices, FNANO 2007
CountryUnited States
CitySnowbird, UT
Period07/4/1807/4/21

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ASJC Scopus subject areas

  • Hardware and Architecture
  • Electrical and Electronic Engineering

Cite this

Takinoue, M., Kiga, D., Shohda, K. I., & Suyama, A. (2007). Oscillator for self-assembled DNA nanomachines. In 4th Conference on Foundations of Nanoscience: Self-Assembled Architectures and Devices, FNANO 2007 (pp. 104-106)