Osmoregulatory inhibition of thermally induced cutaneous vasodilation in passively heated humans

Akira Takamata, Kei Nagashima, Hiroshi Nose, Taketoshi Morimoto

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

We examined the effect of increased plasma osmolality (P(osm)) on cutaneous vasodilatory response to increased esophageal temperature (T(es)) in passively heated human subjects (n = 6). To modify P(osm), subjects were infused with 0.9, 2, or 3% NaCl infusions (Inf) for 90 min on separate days. Infusion rates were 0.2, 0.15, and 0.125 ml-min--1·kg body wt-1 for 0.9, 2, and 3% Inf, respectively, which produced relatively similar plasma volume expansion. Thirty minutes after the end of infusion, subjects immersed their lower legs in a water bath at 42°C (room temperature 28°C) for 60 min after 10 min of preheating control measurements. Passive heating without infusion (NI) served as time control to account for the effect of volume expansion. P(osm) (mosmol/kgH2O) values at the onset of passive heating were 289.9 ± 1.4, 292.1 ± 0.6, 298.7 ± 0.7, and 305.6 ± 0.6 after NI, 0.9% Inf, 2% Inf, and 8% Inf, respectively. The increases in T(es) (ΔT(es)) at equilibrium during passive heating (mean ΔT(es) during 55-60 min)were 0.47 ± 0.08, 0.59 ± 0.08, 0.85 ± 0.13, and 1.09 ± 0.12°C after NI, 0.9% Inf, 2% Inf, and 3% Inf, respectively, which indicates that T(es) at equilibrium increased linearly as P(osm) increased. ΔT(es) required to elicit cutaneous vasodilation (ΔT(es) threshold for cutaneous vasodilation) also increased linearly as P(osm) increased as well as the ΔT(es) threshold for sweating. The calculated increases in these thresholds per unit rise in P(osm) from regression analysis were 0.044°C for the cutaneous vasodilation and 0.034°C for sweating. Thus the ΔT(es) thresholds for cutaneous vasodilation and sweating are shifted to higher ΔT(es) along with the increase in P(osm), and these shifts resulted in the higher increase in T(es) during passive heating.

Original languageEnglish
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Volume273
Issue number1 42-1
Publication statusPublished - 1997 Jul
Externally publishedYes

Fingerprint

Vasodilation
Osmolar Concentration
Skin
Heating
Sweating
Temperature
Plasma Volume
Baths
Leg
Regression Analysis
Water

Keywords

  • Body core temperature threshold
  • Osmoregulation
  • Plasma osmolality
  • Skin blood flow
  • Sweating
  • Thermoregulation

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

Cite this

Osmoregulatory inhibition of thermally induced cutaneous vasodilation in passively heated humans. / Takamata, Akira; Nagashima, Kei; Nose, Hiroshi; Morimoto, Taketoshi.

In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology, Vol. 273, No. 1 42-1, 07.1997.

Research output: Contribution to journalArticle

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abstract = "We examined the effect of increased plasma osmolality (P(osm)) on cutaneous vasodilatory response to increased esophageal temperature (T(es)) in passively heated human subjects (n = 6). To modify P(osm), subjects were infused with 0.9, 2, or 3{\%} NaCl infusions (Inf) for 90 min on separate days. Infusion rates were 0.2, 0.15, and 0.125 ml-min--1·kg body wt-1 for 0.9, 2, and 3{\%} Inf, respectively, which produced relatively similar plasma volume expansion. Thirty minutes after the end of infusion, subjects immersed their lower legs in a water bath at 42°C (room temperature 28°C) for 60 min after 10 min of preheating control measurements. Passive heating without infusion (NI) served as time control to account for the effect of volume expansion. P(osm) (mosmol/kgH2O) values at the onset of passive heating were 289.9 ± 1.4, 292.1 ± 0.6, 298.7 ± 0.7, and 305.6 ± 0.6 after NI, 0.9{\%} Inf, 2{\%} Inf, and 8{\%} Inf, respectively. The increases in T(es) (ΔT(es)) at equilibrium during passive heating (mean ΔT(es) during 55-60 min)were 0.47 ± 0.08, 0.59 ± 0.08, 0.85 ± 0.13, and 1.09 ± 0.12°C after NI, 0.9{\%} Inf, 2{\%} Inf, and 3{\%} Inf, respectively, which indicates that T(es) at equilibrium increased linearly as P(osm) increased. ΔT(es) required to elicit cutaneous vasodilation (ΔT(es) threshold for cutaneous vasodilation) also increased linearly as P(osm) increased as well as the ΔT(es) threshold for sweating. The calculated increases in these thresholds per unit rise in P(osm) from regression analysis were 0.044°C for the cutaneous vasodilation and 0.034°C for sweating. Thus the ΔT(es) thresholds for cutaneous vasodilation and sweating are shifted to higher ΔT(es) along with the increase in P(osm), and these shifts resulted in the higher increase in T(es) during passive heating.",
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