Osteoblast adhesion and matrix mineralization on sol-gel-derived titanium oxide

Maria C. Advincula, Firoz G. Rahemtulla, Rigoberto C. Advincula, Earl T. Ada, Jack E. Lemons, Susan L. Bellis

Research output: Contribution to journalArticle

100 Citations (Scopus)

Abstract

The biological events occurring at the bone-implant interface are influenced by the topography, chemistry and wettability of the implant surface. The surface properties of titanium alloy prepared by either surface sol-gel processing (SSP), or by passivation with nitric acid, were investigated systematically using X-ray photoelectron spectroscopy, scanning electron microscopy, atomic force microscopy and contact angle metrology. The bioreactivity of the substrates was assessed by evaluating MC3T3-E1 osteoblastic cell adhesion, as well as by in vitro formation of mineralized matrix. Surface analysis of sol-gel-derived oxide on Ti6Al4 V substrates showed a predominantly titanium dioxide (TiO2) composition with abundant hydroxyl groups. The surface was highly wettable, rougher and more porous compared to that of the passivated substrate. Significantly more cells adhered to the sol-gel-coated surface, as compared with passivated surfaces, at 1 and 24 h following cell seeding, and a markedly greater number of mineralized nodules were observed on sol-gel coatings. Collectively our results show that the surface properties of titanium alloy can be modified by SSP to enhance the bioreactivity of this biomaterial.

Original languageEnglish
Pages (from-to)2201-2212
Number of pages12
JournalBiomaterials
Volume27
Issue number10
DOIs
Publication statusPublished - 2006 Apr
Externally publishedYes

Fingerprint

Titanium oxides
Osteoblasts
Polymethyl Methacrylate
Sol-gels
Adhesion
Gels
Surface Properties
Titanium
Titanium alloys
Surface properties
Wettability
Substrates
Nitric Acid
Photoelectron Spectroscopy
Atomic Force Microscopy
Biocompatible Materials
Cell Adhesion
Hydroxyl Radical
Electron Scanning Microscopy
Oxides

Keywords

  • Osteoblast
  • Sol-gel technique
  • Surface topography
  • Titanium oxide
  • Wettability

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biomedical Engineering

Cite this

Advincula, M. C., Rahemtulla, F. G., Advincula, R. C., Ada, E. T., Lemons, J. E., & Bellis, S. L. (2006). Osteoblast adhesion and matrix mineralization on sol-gel-derived titanium oxide. Biomaterials, 27(10), 2201-2212. https://doi.org/10.1016/j.biomaterials.2005.11.014

Osteoblast adhesion and matrix mineralization on sol-gel-derived titanium oxide. / Advincula, Maria C.; Rahemtulla, Firoz G.; Advincula, Rigoberto C.; Ada, Earl T.; Lemons, Jack E.; Bellis, Susan L.

In: Biomaterials, Vol. 27, No. 10, 04.2006, p. 2201-2212.

Research output: Contribution to journalArticle

Advincula, MC, Rahemtulla, FG, Advincula, RC, Ada, ET, Lemons, JE & Bellis, SL 2006, 'Osteoblast adhesion and matrix mineralization on sol-gel-derived titanium oxide', Biomaterials, vol. 27, no. 10, pp. 2201-2212. https://doi.org/10.1016/j.biomaterials.2005.11.014
Advincula MC, Rahemtulla FG, Advincula RC, Ada ET, Lemons JE, Bellis SL. Osteoblast adhesion and matrix mineralization on sol-gel-derived titanium oxide. Biomaterials. 2006 Apr;27(10):2201-2212. https://doi.org/10.1016/j.biomaterials.2005.11.014
Advincula, Maria C. ; Rahemtulla, Firoz G. ; Advincula, Rigoberto C. ; Ada, Earl T. ; Lemons, Jack E. ; Bellis, Susan L. / Osteoblast adhesion and matrix mineralization on sol-gel-derived titanium oxide. In: Biomaterials. 2006 ; Vol. 27, No. 10. pp. 2201-2212.
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