Osteoclast-forming suppressing compounds, gargalols A, B, and C, from the edible mushroom Grifola gargal

Jing Wu, Jae Hoon Choi, Miyuki Yoshida, Hirofumi Hirai, Etsuko Harada, Kikuko Masuda, Tomoyuki Koyama, Kazunaga Yazawa, Keiichi Noguchi, Kazuo Nagasawa, Hirokazu Kawagishi

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18 Citations (Scopus)

Abstract

Three novel sterols, gargalols A-C (1-3), and four known ones were isolated from the edible mushroom Grifola gargal. The structures of 1-7 were determined or identified by the interpretation of spectroscopic data. Compounds 1-5 suppressed the formation of osteoclast without toxicity.

Original languageEnglish
Pages (from-to)6576-6581
Number of pages6
JournalTetrahedron
Volume67
Issue number35
DOIs
Publication statusPublished - 2011 Sep 2
Externally publishedYes

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Keywords

  • Grifola gargal
  • Mushroom
  • Structure determination
  • Suppression of the formation of osteoclast

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

Wu, J., Choi, J. H., Yoshida, M., Hirai, H., Harada, E., Masuda, K., Koyama, T., Yazawa, K., Noguchi, K., Nagasawa, K., & Kawagishi, H. (2011). Osteoclast-forming suppressing compounds, gargalols A, B, and C, from the edible mushroom Grifola gargal. Tetrahedron, 67(35), 6576-6581. https://doi.org/10.1016/j.tet.2011.05.091