Overexpression of the adiponectin gene mimics the metabolic and stress resistance effects of calorie restriction, but not the anti-tumor effect

Ryotaro Kamohara, Haruyoshi Yamaza, Tomoshi Tsuchiya, Toshimitsu Komatsu, Seongjoon Park, Hiroko Hayashi, Takuya Chiba, Ryoichi Mori, Shuichi Otabe, Kentaro Yamada, Takeshi Nagayasu, Isao Shimokawa

Research output: Contribution to journalArticle

Abstract

Adiponectin (Adipoq), a peptide hormone secreted from the white adipose tissue, may play a role in the anti-aging and/or anti-tumor effects of calorie restriction (CR). We analyzed metabolic traits in Adipoq gene-overexpressing mice fed ad libitum with a regular diet (RD) or a high-fat diet (HFD), or fed 30% CR of RD initiated at 12. weeks of age. Adipoq-RD and -HFD mice at 6. months of age showed reduced blood glucose and insulin concentrations, and thus increased insulin sensitivity, compared with WT mice fed a RD or a HFD. In the epididymal white adipose tissue in Adipoq mice, senescence-like changes such as upregulation of p53 protein and of biomarkers of inflammation, Cd68 and Ccl2 mRNA, were ameliorated compared with WT-RD and WT-HFD mouse tissues. Resistance to stress induced by lipopolysaccharide was also strengthened in Adipoq mice compared with WT mice. These metabolic changes and stress resistance were also noted in the WT-CR mice, suggesting that Adipoq plays a part in the effect of CR. In contrast, in an allograft tumor growth model, tumor growth was not inhibited in Adipoq mice. The present findings suggest that Adipoq plays a part in the anti-aging, but not in the anti-tumor, effects of CR.

Original languageEnglish
Pages (from-to)46-54
Number of pages9
JournalExperimental Gerontology
Volume64
DOIs
Publication statusPublished - 2015 Apr 1
Externally publishedYes

Fingerprint

Physiological Stress
Adiponectin
Nutrition
Tumors
Genes
High Fat Diet
Neoplasms
Diet
Fats
White Adipose Tissue
Tissue
Aging of materials
Insulin
Peptide Hormones
Biomarkers
Growth
Allografts
Lipopolysaccharides
Insulin Resistance
Blood Glucose

Keywords

  • Adiponectin
  • Calorie restriction
  • ER stress
  • Insulin
  • P53
  • Tumor growth

ASJC Scopus subject areas

  • Ageing
  • Biochemistry
  • Cell Biology
  • Endocrinology
  • Genetics
  • Molecular Biology

Cite this

Overexpression of the adiponectin gene mimics the metabolic and stress resistance effects of calorie restriction, but not the anti-tumor effect. / Kamohara, Ryotaro; Yamaza, Haruyoshi; Tsuchiya, Tomoshi; Komatsu, Toshimitsu; Park, Seongjoon; Hayashi, Hiroko; Chiba, Takuya; Mori, Ryoichi; Otabe, Shuichi; Yamada, Kentaro; Nagayasu, Takeshi; Shimokawa, Isao.

In: Experimental Gerontology, Vol. 64, 01.04.2015, p. 46-54.

Research output: Contribution to journalArticle

Kamohara, R, Yamaza, H, Tsuchiya, T, Komatsu, T, Park, S, Hayashi, H, Chiba, T, Mori, R, Otabe, S, Yamada, K, Nagayasu, T & Shimokawa, I 2015, 'Overexpression of the adiponectin gene mimics the metabolic and stress resistance effects of calorie restriction, but not the anti-tumor effect', Experimental Gerontology, vol. 64, pp. 46-54. https://doi.org/10.1016/j.exger.2015.02.011
Kamohara, Ryotaro ; Yamaza, Haruyoshi ; Tsuchiya, Tomoshi ; Komatsu, Toshimitsu ; Park, Seongjoon ; Hayashi, Hiroko ; Chiba, Takuya ; Mori, Ryoichi ; Otabe, Shuichi ; Yamada, Kentaro ; Nagayasu, Takeshi ; Shimokawa, Isao. / Overexpression of the adiponectin gene mimics the metabolic and stress resistance effects of calorie restriction, but not the anti-tumor effect. In: Experimental Gerontology. 2015 ; Vol. 64. pp. 46-54.
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