Oxidative C-H/C-H coupling of azine and indole/pyrrole nuclei: Palladium catalysis and synthesis of eudistomin U

Atsushi D. Yamaguchi; Debashis Mandal; Junichiro Yamaguchi; Kenichiro Itami

doi:10.1246/cl.2011.555

Oxidative C-H/C-H coupling of azine and indole/pyrrole nuclei

Palladium catalysis and synthesis of eudistomin U

Atsushi D. Yamaguchi, Debashis Mandal, Junichiro Yamaguchi, Kenichiro Itami

Research output: Contribution to journal › Review article

96 Citations (Scopus)

Abstract

We have developed a palladium-catalyzed C-H/C-H coupling reaction of indoles or pyrroles with azine N-oxides. The reaction proceeds selectively at the C3 position of indoles/pyrroles and the C2 position of azine N-oxides. Furthermore, we have accomplished the synthesis of marine indole alkaloid eudistomin U by utilizing this newly developed C-H/C-H coupling reaction.

Original language	English
Pages (from-to)	555-557
Number of pages	3
Journal	Chemistry Letters
Volume	40
Issue number	6
DOIs	https://doi.org/10.1246/cl.2011.555
Publication status	Published - 2011
Externally published	Yes

Fingerprint

Indoles

Pyrroles

Palladium

Oxides

Catalysis

Indole Alkaloids

eudistomin U

indole

ASJC Scopus subject areas

Chemistry(all)

Cite this

Yamaguchi, A. D., Mandal, D., Yamaguchi, J., & Itami, K. (2011). Oxidative C-H/C-H coupling of azine and indole/pyrrole nuclei: Palladium catalysis and synthesis of eudistomin U. Chemistry Letters, 40(6), 555-557. https://doi.org/10.1246/cl.2011.555

Oxidative C-H/C-H coupling of azine and indole/pyrrole nuclei : Palladium catalysis and synthesis of eudistomin U. / Yamaguchi, Atsushi D.; Mandal, Debashis; Yamaguchi, Junichiro; Itami, Kenichiro.

In: Chemistry Letters, Vol. 40, No. 6, 2011, p. 555-557.

Research output: Contribution to journal › Review article

Yamaguchi, AD, Mandal, D, Yamaguchi, J & Itami, K 2011, 'Oxidative C-H/C-H coupling of azine and indole/pyrrole nuclei: Palladium catalysis and synthesis of eudistomin U', Chemistry Letters, vol. 40, no. 6, pp. 555-557. https://doi.org/10.1246/cl.2011.555

Yamaguchi AD, Mandal D, Yamaguchi J, Itami K. Oxidative C-H/C-H coupling of azine and indole/pyrrole nuclei: Palladium catalysis and synthesis of eudistomin U. Chemistry Letters. 2011;40(6):555-557. https://doi.org/10.1246/cl.2011.555

Yamaguchi, Atsushi D. ; Mandal, Debashis ; Yamaguchi, Junichiro ; Itami, Kenichiro. / Oxidative C-H/C-H coupling of azine and indole/pyrrole nuclei : Palladium catalysis and synthesis of eudistomin U. In: Chemistry Letters. 2011 ; Vol. 40, No. 6. pp. 555-557.

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Access to Document

10.1246/cl.2011.555