Oxidative C-H/C-H coupling of azine and indole/pyrrole nuclei: Palladium catalysis and synthesis of eudistomin U

Atsushi D. Yamaguchi, Debashis Mandal, Junichiro Yamaguchi, Kenichiro Itami

Research output: Contribution to journalReview article

96 Citations (Scopus)

Abstract

We have developed a palladium-catalyzed C-H/C-H coupling reaction of indoles or pyrroles with azine N-oxides. The reaction proceeds selectively at the C3 position of indoles/pyrroles and the C2 position of azine N-oxides. Furthermore, we have accomplished the synthesis of marine indole alkaloid eudistomin U by utilizing this newly developed C-H/C-H coupling reaction.

Original languageEnglish
Pages (from-to)555-557
Number of pages3
JournalChemistry Letters
Volume40
Issue number6
DOIs
Publication statusPublished - 2011

ASJC Scopus subject areas

  • Chemistry(all)

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