Oxidative stress caused by TiO2 nanoparticles under UV irradiation is due to UV irradiation not through nanoparticles

Akihiro Moriyama, Ikuho Yamada, Junko Takahashi, Hitoshi Iwahashi

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

Currently, nanoparticles are used in various commercial products. One of the most common nanoparticles is titanium dioxide (TiO2). It has a catalytic activity and UV absorption, and generates reactive oxygen species (ROS). This catalytic activity of TiO2 nanoparticles was believed to be capable of killing a wide range of microorganisms. In the environment, the unique properties of TiO2 nanoparticles can be maintained; therefore, the increasing use of TiO2 nanoparticles is raising concerns about their environmental risks. Thus, assessment of the biological and ecological effects of TiO2-NOAAs is necessary. In this study, we assessed the effect of TiO2-NOAAs for S. cerevisiae using DNA microarray. To compare yeast cells under various conditions, six treatment conditions were prepared (1. adsorbed fraction to TiO2-NOAA under UV; 2. non-adsorbed fraction to TiO2-NOAA under UV; 3. adsorbed fraction to TiO2-NOAA without UV; 4. non-adsorbed fraction to TiO2-NOAA without UV; 5. under UV; and 6. untreated control). The result of the DNA microarray analysis, suggested that yeast cells that are adsorbed by TiO2-NOAA under UV irradiation suffer oxidative stress and this stress response was similar to that by only UV irradiation. We concluded that the effect of TiO2-NOAAs on yeast cells under UV irradiation is not caused by TiO2-NOAA but UV irradiation.

Original languageEnglish
Pages (from-to)144-150
Number of pages7
JournalChemico-Biological Interactions
Volume294
DOIs
Publication statusPublished - 2018 Oct 1
Externally publishedYes

Keywords

  • DNA microarray
  • ROS generated by TiO-NOAA
  • Saccharomyces cerevisiae
  • TiO nanoparticles

ASJC Scopus subject areas

  • Toxicology

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