Oxidised low-density lipoprotein concentrations and physical activity status in older adults: The WASEDA active life study

Jong Hwan Park, Masashi Miyashita, Masaki Takahashi, Kazuhiro Harada, Kanae Takaizumi, Hyun Shik Kim, Katsuhiko Suzuki, Yoshio Nakamura

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Aim: Oxidised low-density lipoprotein (LDL) is considered a risk marker for cardiovascular disease. However, it remains unclear whether oxidised LDL concentrations differ with the physical activity status in older adults. The purpose of this study was to examine the relationship between the amount of physical activity and oxidised LDL in older adults. Methods: Twenty-seven older adults (aged 69.9 ± 4.3 years, mean ± SD.; 16 female and 11 male) were analysed in the cross-sectional design. Prior to blood collection, participants were asked to wear an uniaxial accelerometer for 4 consecutive weeks to determine the physical activity status. After a 48-h period of physical activity avoidance and a 10-h overnight fast, fasting venous blood samples were obtained from each participant. Results: Fasting plasma oxidised LDL concentrations and plasma monocyte chemoattractant protein- 1 concentrations were negatively correlated with the amount of physical activity (r = -0.409, p = 0.034; r = -0.385, p = 0.047, respectively). Conclusions: This study demonstrates that regular physical activity may play a protective role in the oxidation of LDL in older adults.

Original languageEnglish
Pages (from-to)568-573
Number of pages6
JournalJournal of Atherosclerosis and Thrombosis
Volume18
Issue number7
DOIs
Publication statusPublished - 2011

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Fasting
Blood
Plasmas
Chemokine CCL2
LDL Lipoproteins
Accelerometers
Blood Proteins
Cardiovascular Diseases
Wear of materials
Oxidation
oxidized low density lipoprotein

Keywords

  • Cardiovascular disease
  • Older adults
  • Oxidised low-density lipoprotein
  • Physical activity status

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Internal Medicine
  • Biochemistry, medical

Cite this

Oxidised low-density lipoprotein concentrations and physical activity status in older adults : The WASEDA active life study. / Park, Jong Hwan; Miyashita, Masashi; Takahashi, Masaki; Harada, Kazuhiro; Takaizumi, Kanae; Kim, Hyun Shik; Suzuki, Katsuhiko; Nakamura, Yoshio.

In: Journal of Atherosclerosis and Thrombosis, Vol. 18, No. 7, 2011, p. 568-573.

Research output: Contribution to journalArticle

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