Oxygen-binding profile of the iron porphyrin complex embedded in polymerized liposome

Effect of the polymerized liposome on the stability and the oxygen-binding ability of the iron porphyrin complex

E. Tsuchida, Hiroyuki Nishide, M. Yuasa

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7 Citations (Scopus)

Abstract

5,10,15,2O-Tetra(01,01,01,01-0-(2,' 2'-dimethyl-20'-(2”-trimethylarnmonioethyl) phosphonatoxyeicosanamido)phenyl)porphinatoiron(II) (lipidheme) complex embedded in polymerized liposome was prepared by polymerizing 1-(9-(p-vinylbenzoyl)nonanoyl)-2-O-octadecyl-ruc-glycero- 3-phosphocholine in the presence of lipid-heme under ultraviolet irradiation. The polymerization proceeded rapidly, and the reduction of the hemin to the heme occurred spontaneously during the polymerization. The lipid-heme complex embedded in the polymerized liposome bound molecular oxygen reversibly under physiological conditions (pH 7, 37ºC) and was chemically, physically, and mechanically stable during storage for a long period and even in a high-speed flow system. The oxygenbinding affinity was not affected by the type of medium due to the effect of the rigid polymerized liposome.

Original languageEnglish
Pages (from-to)333-341
Number of pages9
JournalJournal of macromolecular science. Chemistry
Volume24
Issue number3-4
DOIs
Publication statusPublished - 1987

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Liposomes
Porphyrins
Heme
Iron
Oxygen
Lipids
Polymerization
Hemin
Phosphorylcholine
Molecular oxygen
Irradiation

ASJC Scopus subject areas

  • Chemistry(all)
  • Polymers and Plastics
  • Materials Chemistry
  • Ceramics and Composites

Cite this

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title = "Oxygen-binding profile of the iron porphyrin complex embedded in polymerized liposome: Effect of the polymerized liposome on the stability and the oxygen-binding ability of the iron porphyrin complex",
abstract = "5,10,15,2O-Tetra(01,01,01,01-0-(2,' 2'-dimethyl-20'-(2”-trimethylarnmonioethyl) phosphonatoxyeicosanamido)phenyl)porphinatoiron(II) (lipidheme) complex embedded in polymerized liposome was prepared by polymerizing 1-(9-(p-vinylbenzoyl)nonanoyl)-2-O-octadecyl-ruc-glycero- 3-phosphocholine in the presence of lipid-heme under ultraviolet irradiation. The polymerization proceeded rapidly, and the reduction of the hemin to the heme occurred spontaneously during the polymerization. The lipid-heme complex embedded in the polymerized liposome bound molecular oxygen reversibly under physiological conditions (pH 7, 37ºC) and was chemically, physically, and mechanically stable during storage for a long period and even in a high-speed flow system. The oxygenbinding affinity was not affected by the type of medium due to the effect of the rigid polymerized liposome.",
author = "E. Tsuchida and Hiroyuki Nishide and M. Yuasa",
year = "1987",
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pages = "333--341",
journal = "Journal of Macromolecular Science - Pure and Applied Chemistry",
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publisher = "Taylor and Francis Ltd.",
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TY - JOUR

T1 - Oxygen-binding profile of the iron porphyrin complex embedded in polymerized liposome

T2 - Effect of the polymerized liposome on the stability and the oxygen-binding ability of the iron porphyrin complex

AU - Tsuchida, E.

AU - Nishide, Hiroyuki

AU - Yuasa, M.

PY - 1987

Y1 - 1987

N2 - 5,10,15,2O-Tetra(01,01,01,01-0-(2,' 2'-dimethyl-20'-(2”-trimethylarnmonioethyl) phosphonatoxyeicosanamido)phenyl)porphinatoiron(II) (lipidheme) complex embedded in polymerized liposome was prepared by polymerizing 1-(9-(p-vinylbenzoyl)nonanoyl)-2-O-octadecyl-ruc-glycero- 3-phosphocholine in the presence of lipid-heme under ultraviolet irradiation. The polymerization proceeded rapidly, and the reduction of the hemin to the heme occurred spontaneously during the polymerization. The lipid-heme complex embedded in the polymerized liposome bound molecular oxygen reversibly under physiological conditions (pH 7, 37ºC) and was chemically, physically, and mechanically stable during storage for a long period and even in a high-speed flow system. The oxygenbinding affinity was not affected by the type of medium due to the effect of the rigid polymerized liposome.

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