OXYGEN-EXCHANGE REACTION BETWEEN ARTIFICIAL LUNG DEVICE

THE HEME EMBEDDED IN POLYMERIZED LIPO LIPOSOME AS AN ARTIFICIAL OXYGEN CARRIER.

Makoto Yuasa, Etsuo Hasegawa, Hiroyuki Nishide, Eishun Tsuchida

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

An oxygen-supplying medium (OSM), which was prepared by embedding a synthetic heme complex in a bilayer of polymerized lipid liposome (polylipid liposome/heme), could blind molecular oxygen reversibly under physiological conditions. The oxygen-exchange reaction of OSM with blood was examined by using a liquid/liquid artificial lung device. For example, deoxy-blood (p//S(O//2) equals 0 torr) was passed countercurrent to oxy-OSM (p//S(O//2) equals 154 torr) through hollow fibers of the device to provide oxy-blood (p//b(O//2) equals 57 torr). The OSM was physicochemically and mechanically stable under strong shear stress during the passage through the hollow fibers and acted as the oxygen mediator to blood.

Original languageEnglish
Pages (from-to)661-668
Number of pages8
JournalJournal of macromolecular science. Chemistry
VolumeA24
Issue number6
Publication statusPublished - 1987

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Liposomes
Heme
Oxygen
Blood
Molecular oxygen
Fibers
Liquids
Lipids
Shear stress

ASJC Scopus subject areas

  • Engineering(all)

Cite this

OXYGEN-EXCHANGE REACTION BETWEEN ARTIFICIAL LUNG DEVICE : THE HEME EMBEDDED IN POLYMERIZED LIPO LIPOSOME AS AN ARTIFICIAL OXYGEN CARRIER. / Yuasa, Makoto; Hasegawa, Etsuo; Nishide, Hiroyuki; Tsuchida, Eishun.

In: Journal of macromolecular science. Chemistry, Vol. A24, No. 6, 1987, p. 661-668.

Research output: Contribution to journalArticle

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abstract = "An oxygen-supplying medium (OSM), which was prepared by embedding a synthetic heme complex in a bilayer of polymerized lipid liposome (polylipid liposome/heme), could blind molecular oxygen reversibly under physiological conditions. The oxygen-exchange reaction of OSM with blood was examined by using a liquid/liquid artificial lung device. For example, deoxy-blood (p//S(O//2) equals 0 torr) was passed countercurrent to oxy-OSM (p//S(O//2) equals 154 torr) through hollow fibers of the device to provide oxy-blood (p//b(O//2) equals 57 torr). The OSM was physicochemically and mechanically stable under strong shear stress during the passage through the hollow fibers and acted as the oxygen mediator to blood.",
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