Oxygen permeability of biodegradable copolycaprolactones

Shenguo Wang, Hiroyuki Nishide, Eishun Tsuchida

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Abstract

Polycaprolactone is one of the biodegradable polymers with good drug permeability. In the present paper, polycaprolactone and three kinds of copolycaprolactone-polycaprolactone-poly(ethylene oxide)-polycaprolactone triblock copolymer (PCE), polycaprolactone/polycaprolactone-poly(ethylene oxide)/polylactide tricomponents random block copolymer (PCEL) and polycaprolactone/ poly(ethylene terephthalate) random block copolymer (PETCL)-were synthesized. The biodegradation behavior of these polymers were shown by degradation tests in vitro, ex vivo and in vivo. The oxygen permeabilities of these polymers were in the range of 10-10 ∼ 10-9 cm3 (STP) cm/cm2 sec cm Hg. Copolymers PCE and PCEL displayed O2 and N2 permeability coefficients (PO2/PN2) ratios of about 9. The effects of composition and crystallinity of the copolymers on biodegradability and the oxygen permeability of the polymer were discussed.

Original languageEnglish
Pages (from-to)282-286
Number of pages5
JournalPolymers for Advanced Technologies
Volume10
Issue number5
Publication statusPublished - 1999 May

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Keywords

  • Biodegradability
  • Copolymer
  • Oxygen permeability
  • Polycaprolactone

ASJC Scopus subject areas

  • Polymers and Plastics

Cite this

Wang, S., Nishide, H., & Tsuchida, E. (1999). Oxygen permeability of biodegradable copolycaprolactones. Polymers for Advanced Technologies, 10(5), 282-286.