Oxygen-transport and solution properties of polylipid/hb vesicles (arc)

Shinji Takeoka, Etsuo Hasegawa, Hiroyuki Nishide, Eishun Tsuchida, Sadayoshi Sekiguchi

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Polymerized phospholipid vesicle encapsulating Hb (polylipid/Hb vesicle) was prepared from a mixture of unsaturated phospholipid, cholesterol and unsaturated fatty acid and polymerization by y-ray irradiation. The average radius of resulting vesicles was 203 39 nm and concentrated Hb (30 wt%) was efficiently encapsulated. y-Ray polymerization proceeds theoretically at low temperature (4C). Pso and oxygen transporting efficiency were adjusted to 40 mmHg and 40%, respectively. Oncotic pressure and solution viscosity can be controlled to the same values as blood.

Original languageEnglish
Pages (from-to)399-404
Number of pages6
JournalBiomaterials, Artificial Cells and Immobilization Biotechnology
Volume20
Issue number4 --Feb
DOIs
Publication statusPublished - 1992 Jan

ASJC Scopus subject areas

  • Medicine(all)

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