Oxygen transporting ability of lipidheme microspheres as a totally synthetic red cell substitute

Teruyuki Komatsu, Ayako Kuronuma, Yasuko Muramatsu, Hiroyuki Nishide, Eishun Tsuchida, Toru Kakizaki, Koichi Kobayashi

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

O2 Binding parameters, O2 solubility and in vivo O2 transporting ability of a lipidheme microsphere as a totally synthetic red cell substitute are described. The O2-binding affinity of the lipidheme microsphere (P1/2(O2): about 40 torr at 37°C) was slightly lower than that of human blood, and its O2 association and dissociation rate constants were larger than those of hemoglobin. The O2 solubility of this solution was estimated; an aqueous solution containing a high amount of dissolved oxygen can be prepared by prescription. The lipidheme microsphere suspension was intravenously injected into hemorrhagic beagles and the circulation lifetime of each constituent of the artificial red cell was determined. The O2 consumption by the lipid-heme was estimated to be about 15% of the total O2 consumption. These results suggest that the lipidheme microsphere has the ability to act as an oxygen carrier in the blood stream.

Original languageEnglish
Pages (from-to)207-215
Number of pages9
JournalArtificial Organs Today (Japan)
Volume5
Issue number3
Publication statusPublished - 1996

Keywords

  • Artificial red cell
  • Exchange transfusion
  • Lipid microsphere
  • Lipidheme microsphere
  • Oxygen transport
  • Red cell substitute

ASJC Scopus subject areas

  • Biomedical Engineering

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    Komatsu, T., Kuronuma, A., Muramatsu, Y., Nishide, H., Tsuchida, E., Kakizaki, T., & Kobayashi, K. (1996). Oxygen transporting ability of lipidheme microspheres as a totally synthetic red cell substitute. Artificial Organs Today (Japan), 5(3), 207-215.