Fájdalom és opioidok

Translated title of the contribution: Pain and opioids

Marianna Murányi, Zsolt Radak

Research output: Contribution to journalReview article

9 Citations (Scopus)

Abstract

Noxious stimuli cause pain to protect the body from harmful situations and attract attention to pathophysiologic changes of the body. Specific receptors of pain (nociceptors) can be found all over our body. Pain initiates protecting mechanisms such as vegetative and motor reflexes, and emotional, behavioral changes. However, chronic pain is practically useless and leads to pathopsychological changes. There are several ways to relieve pain including non-steroid anti-inflammatory agents, opioids, neurosurgical and non-invasive methods. Central and periferal effects of opioids can be realized through opioid receptors of the central and the enteric nervous system. In the central nervous system, they can inhibit the perception of pain or change the emotional reactions. Opioids are indicated in postoperative pain, neuropathic pain and cancer. However, the use of opioids has severe side-effects such as breathing depression and the development of tolerance and dependence which do not make opioids optimal painkillers. There are several laboratories in Hungary and abroad working on the design of optimal pain relievers. Furthermore, the euphoric effects of opioids lead to abuse which makes the research important on the mechanisms of opioid addiction. Taken together, opioid research, the design of new compounds and the exploration of the mechanisms of opiate addiction are very important.

Original languageHungarian
Pages (from-to)2363-2370
Number of pages8
JournalOrvosi Hetilap
Volume149
Issue number50
DOIs
Publication statusPublished - 2008 Dec 14
Externally publishedYes

Fingerprint

Opioid Analgesics
Pain
Nociceptors
Central Nervous System
Enteric Nervous System
Opioid-Related Disorders
Pain Perception
Hungary
Opioid Receptors
Neuralgia
Postoperative Pain
Chronic Pain
Reflex
Respiration
Anti-Inflammatory Agents
Research Design
Depression
Research
Neoplasms

Keywords

  • Analgesy
  • Opioids
  • Pain

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Fájdalom és opioidok. / Murányi, Marianna; Radak, Zsolt.

In: Orvosi Hetilap, Vol. 149, No. 50, 14.12.2008, p. 2363-2370.

Research output: Contribution to journalReview article

Murányi, M & Radak, Z 2008, 'Fájdalom és opioidok', Orvosi Hetilap, vol. 149, no. 50, pp. 2363-2370. https://doi.org/10.1556/OH.2008.28449
Murányi, Marianna ; Radak, Zsolt. / Fájdalom és opioidok. In: Orvosi Hetilap. 2008 ; Vol. 149, No. 50. pp. 2363-2370.
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