Paired pulse ratio analysis of insulin-induced synaptic plasticity in the snail brain

Jun Murakami, Ryuichi Okada, Yutaka Fujito, Manabu Sakakibara, Ken Lukowiak, Etsuro Ito

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Insulin's action in the brain can directly alter cognitive functioning. We have recently shown that molluscan insulin-related peptides are upregulated following a conditioned taste aversion (CTA) training procedure. In addition, when mammalian insulin is superfused over the isolated Lymnaea stagnalis central nervous system, it elicits long-term synaptic enhancement at the monosynaptic connection between the cerebral giant cell and the buccal 1 (B1) motor neuron. This synaptic enhancement is thought to be a neural correlate of CTA. Here, we examined whether the observed changes in synaptic plasticity were the result of presynaptic and/or postsynaptic alterations using the paired pulse procedure. The paired pulse ratio was unaltered following insulin application, suggesting that insulin's effects on synaptic plasticity are mediated postsynaptically in the B1 motor neuron. Thus, it was suggested that postsynaptic changes need to be considered when insulin's actions on synaptic plasticity are examined.

Original languageEnglish
Pages (from-to)1771-1773
Number of pages3
JournalJournal of Experimental Biology
Volume216
Issue number10
DOIs
Publication statusPublished - 2013 May 1
Externally publishedYes

Keywords

  • Conditioned taste aversion
  • Insulin
  • Lymnaea
  • Paired pulse ratio
  • Synaptic plasticity

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Physiology
  • Aquatic Science
  • Animal Science and Zoology
  • Molecular Biology
  • Insect Science

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