Abstract
A palladium-catalyzed carbothiolation via the reaction of a σ-alkyl palladium intermediate with a TIPS thioether is described. It was found that the use of Cs2CO3, (IPr)Pd(allyl)Cl, and a TIPS thioether was key to obtaining alkyl aryl and dialkyl sulfides in high yield through the reaction of a σ-alkyl palladium intermediate. The developed reaction is applicable to a wide range of substrates and thiols.
Original language | English |
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Pages (from-to) | 8280-8284 |
Number of pages | 5 |
Journal | Organic Letters |
Volume | 21 |
Issue number | 20 |
DOIs | |
Publication status | Published - 2019 Oct 18 |
ASJC Scopus subject areas
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry