Palladium-Catalyzed Mizoroki-Heck Reaction of Nitroarenes and Styrene Derivatives

Toshimasa Okita, Kitty K. Asahara, Kei Muto, Junichiro Yamaguchi

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

We have developed a Mizoroki-Heck reaction of nitroarenes with alkenes under palladium catalysis. The use of a Pd/BrettPhos catalyst promoted the alkenylation, whereas other catalysts led to a decrease in the product yield. In addition to nitroarenes, nitroheteroarenes were also applicable to the present reaction. The combination of a nucleophilic aromatic substitution (SNAr) with the denitrative alkenylation produced a multifunctionalized arene in a one-pot operation.

Original languageEnglish
Pages (from-to)3205-3208
Number of pages4
JournalOrganic Letters
Volume22
Issue number8
DOIs
Publication statusPublished - 2020 Apr 17

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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