Para-Sports can Promote Functional Reorganization in the Ipsilateral Primary Motor Cortex of Lower Limbs Amputee

Tomoya Nakanishi, Nobuaki Mizuguchi, Kento Nakagawa, Kimitaka Nakazawa*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Background. Drastic functional reorganization was observed in the ipsilateral primary motor cortex (M1) of a Paralympic long jumper with a unilateral below-knee amputation in our previous study. However, it remains unclear whether long-term para-sports are associated with ipsilateral M1 reorganization since only 1 athlete with amputation was investigated. Objective. This study aimed to investigate the relationship between the long-term para-sports and ipsilateral M1 reorganization after lower limb amputation. Methods. Lower limb rhythmic muscle contraction tasks with functional magnetic resonance imaging and T1-weighted structural imaging were performed in 30 lower limb amputees with different para-sports experiences in the chronic phase. Results. Brain activity in the ipsilateral primary motor and somatosensory areas (SM1) as well as the contralateral dorsolateral prefrontal cortex, SM1, and inferior temporal gyrus showed a positive correlation with the years of routine para-sports participation (sports years) during contraction of the amputated knee. Indeed, twelve of the 30 participants who exhibited significant ipsilateral M1 activation during amputated knee contraction had a relatively longer history of para-sports participation. No significant correlation was found in the structural analysis. Conclusions. Long-term para-sports could lead to extensive reorganization at the brain network level, not only bilateral M1 reorganization but also reorganization of the frontal lobe and visual pathways. These results suggest that the interaction of injury-induced and use-dependent cortical plasticity might bring about drastic reorganization in lower limb amputees.

Original languageEnglish
Pages (from-to)1112-1123
Number of pages12
JournalNeurorehabilitation and Neural Repair
Volume35
Issue number12
DOIs
Publication statusPublished - 2021 Dec

Keywords

  • amputees
  • lower extremity
  • magnetic resonance imaging
  • motor cortex
  • para-sports
  • prefrontal lobe

ASJC Scopus subject areas

  • Rehabilitation
  • Neurology
  • Clinical Neurology

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