Partial seeding policy for controlling size distribution of product crystal by batch cooling crystallization

Research output: Contribution to journalArticle

Abstract

Simulations were performed for seeded batch cooling crystallization. In industry, partial seeding is often utilized, where a small amount of seed crystal is added to trigger secondary nucleation and grown secondary nuclei are obtained as the product. Partial seeding was investigated by computer simulation in this study. First, the coefficient of variation (CV) of the product crystal size distribution (CSD) was proven to take two local minima, one in the partial seeding range and the other in the range in which the product was mainly composed of seed-grown crystals. The local minimum point in the partial seeding range was considered as an optimum condition for partial seeding. Then, CSDs of grown seed crystals and nuclei were simulated at the optimum seed-loading ratio. As a result, the product was found to be composed mainly of grown secondary nuclei induced by grown seed crystals and grown secondary nuclei themselves. Partial seeding performed at the optimum seed-loading ratio yielded a reasonably good product of unimodal size distribution. Finally, the optimum seed-loading ratio was correlated with the cooling rate and seed crystal size and was found to depend on the cooling rate and more strongly on the seed crystal size. As the cooling rate was decreased, the minimum CV was shown to decrease and the mean size at the optimum seed-loading ratio was shown to increase.

Original languageEnglish
Pages (from-to)501-507
Number of pages7
JournalJournal of Chemical Engineering of Japan
Volume52
Issue number6
DOIs
Publication statusPublished - 2019 Jan 1

Fingerprint

Crystallization
Cooling
Seed
Crystals
Nucleation
Computer simulation
Industry

Keywords

  • Batch Cooling Crystallization
  • Crystal Size Distribution
  • Partial Seeding
  • Secondary Nucleation
  • Simulation

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)

Cite this

@article{2a74b83b08df4548a28598f67f1fa6da,
title = "Partial seeding policy for controlling size distribution of product crystal by batch cooling crystallization",
abstract = "Simulations were performed for seeded batch cooling crystallization. In industry, partial seeding is often utilized, where a small amount of seed crystal is added to trigger secondary nucleation and grown secondary nuclei are obtained as the product. Partial seeding was investigated by computer simulation in this study. First, the coefficient of variation (CV) of the product crystal size distribution (CSD) was proven to take two local minima, one in the partial seeding range and the other in the range in which the product was mainly composed of seed-grown crystals. The local minimum point in the partial seeding range was considered as an optimum condition for partial seeding. Then, CSDs of grown seed crystals and nuclei were simulated at the optimum seed-loading ratio. As a result, the product was found to be composed mainly of grown secondary nuclei induced by grown seed crystals and grown secondary nuclei themselves. Partial seeding performed at the optimum seed-loading ratio yielded a reasonably good product of unimodal size distribution. Finally, the optimum seed-loading ratio was correlated with the cooling rate and seed crystal size and was found to depend on the cooling rate and more strongly on the seed crystal size. As the cooling rate was decreased, the minimum CV was shown to decrease and the mean size at the optimum seed-loading ratio was shown to increase.",
keywords = "Batch Cooling Crystallization, Crystal Size Distribution, Partial Seeding, Secondary Nucleation, Simulation",
author = "Joi Unno and Izumi Hirasawa",
year = "2019",
month = "1",
day = "1",
doi = "10.1252/jcej.18we272",
language = "English",
volume = "52",
pages = "501--507",
journal = "Journal of Chemical Engineering of Japan",
issn = "0021-9592",
publisher = "Society of Chemical Engineers, Japan",
number = "6",

}

TY - JOUR

T1 - Partial seeding policy for controlling size distribution of product crystal by batch cooling crystallization

AU - Unno, Joi

AU - Hirasawa, Izumi

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Simulations were performed for seeded batch cooling crystallization. In industry, partial seeding is often utilized, where a small amount of seed crystal is added to trigger secondary nucleation and grown secondary nuclei are obtained as the product. Partial seeding was investigated by computer simulation in this study. First, the coefficient of variation (CV) of the product crystal size distribution (CSD) was proven to take two local minima, one in the partial seeding range and the other in the range in which the product was mainly composed of seed-grown crystals. The local minimum point in the partial seeding range was considered as an optimum condition for partial seeding. Then, CSDs of grown seed crystals and nuclei were simulated at the optimum seed-loading ratio. As a result, the product was found to be composed mainly of grown secondary nuclei induced by grown seed crystals and grown secondary nuclei themselves. Partial seeding performed at the optimum seed-loading ratio yielded a reasonably good product of unimodal size distribution. Finally, the optimum seed-loading ratio was correlated with the cooling rate and seed crystal size and was found to depend on the cooling rate and more strongly on the seed crystal size. As the cooling rate was decreased, the minimum CV was shown to decrease and the mean size at the optimum seed-loading ratio was shown to increase.

AB - Simulations were performed for seeded batch cooling crystallization. In industry, partial seeding is often utilized, where a small amount of seed crystal is added to trigger secondary nucleation and grown secondary nuclei are obtained as the product. Partial seeding was investigated by computer simulation in this study. First, the coefficient of variation (CV) of the product crystal size distribution (CSD) was proven to take two local minima, one in the partial seeding range and the other in the range in which the product was mainly composed of seed-grown crystals. The local minimum point in the partial seeding range was considered as an optimum condition for partial seeding. Then, CSDs of grown seed crystals and nuclei were simulated at the optimum seed-loading ratio. As a result, the product was found to be composed mainly of grown secondary nuclei induced by grown seed crystals and grown secondary nuclei themselves. Partial seeding performed at the optimum seed-loading ratio yielded a reasonably good product of unimodal size distribution. Finally, the optimum seed-loading ratio was correlated with the cooling rate and seed crystal size and was found to depend on the cooling rate and more strongly on the seed crystal size. As the cooling rate was decreased, the minimum CV was shown to decrease and the mean size at the optimum seed-loading ratio was shown to increase.

KW - Batch Cooling Crystallization

KW - Crystal Size Distribution

KW - Partial Seeding

KW - Secondary Nucleation

KW - Simulation

UR - http://www.scopus.com/inward/record.url?scp=85069717702&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85069717702&partnerID=8YFLogxK

U2 - 10.1252/jcej.18we272

DO - 10.1252/jcej.18we272

M3 - Article

AN - SCOPUS:85069717702

VL - 52

SP - 501

EP - 507

JO - Journal of Chemical Engineering of Japan

JF - Journal of Chemical Engineering of Japan

SN - 0021-9592

IS - 6

ER -