Patchwork coating of fragmented ultra-thin films and their biomedical applications in burn therapy and antithrombotic coating

Yosuke Okamura, Yu Nagase, Shinji Takeoka

Research output: Contribution to journalReview articlepeer-review

3 Citations (Scopus)

Abstract

We have proposed free-standing centimeter-sized ultra-thin films (nanosheets) for biomedical applications. Such nanosheets exhibit unique properties such as transparency, flexibility, and good adhesiveness. However, they are only easily adhered to broad and flat surfaces due to their dimensions. To this end, we recently proposed an innovative nanomaterial: the nanosheets fragmented into submillimeter-size pieces. Intriguingly, such fragmented nanosheets could be adhered to uneven and irregular surfaces in addition to flat surfaces in a spread-out "patchwork" manner. We herein review the fabrication procedure and characterization of fragmented nanosheets composed of biodegradable polyesters and thermostable bio-friendly polymers, and their biomedical applications in burn therapy and antithrombotic coating using a "patchwork coating".

Original languageEnglish
Pages (from-to)7604-7614
Number of pages11
JournalMaterials
Volume8
Issue number11
DOIs
Publication statusPublished - 2015

Keywords

  • Biocompatibility
  • Biodegradability
  • Fragmentation
  • Patchwork
  • Phosphorylcholine
  • Poly(L-lactic acid)
  • Ultra-thin films (nanosheets)

ASJC Scopus subject areas

  • Materials Science(all)

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