Pd- and Cu-catalyzed C-H arylation of indazoles

Keika Hattori, Kazuya Yamaguchi, Junichiro Yamaguchi, Kenichiro Itami

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

The palladium- and copper-catalyzed C-H arylation reactions of 1H- and 2H-indazoles with haloarenes are described. A PdCl 2/phen/Ag 2CO 3/K 3PO 4 catalytic system is effective for the C-H arylation of 1H- and 2H-indazoles with haloarenes, whereas a less expensive CuI/phen/LiOt-Bu catalytic system is applicable to the C-H coupling of substituted 2H-indazoles and iodoarenes. The utility of newly developed catalyst was demonstrated in the rapid synthesis of YC-1 (an antitumor agent) and YD-3 (platelet anti-aggregating agent). These new reactions represent important direct functionalization tools of indazoles, well-known bioisosteres of pharmaceutically important indole core.

Original languageEnglish
Pages (from-to)7605-7612
Number of pages8
JournalTetrahedron
Volume68
Issue number37
DOIs
Publication statusPublished - 2012 Sep 16
Externally publishedYes

Fingerprint

Indazoles
Palladium
Platelets
Antineoplastic Agents
Copper
Blood Platelets
Catalysts

Keywords

  • C-H arylation
  • Catalysis
  • Heterobiaryl
  • Indazole

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

Pd- and Cu-catalyzed C-H arylation of indazoles. / Hattori, Keika; Yamaguchi, Kazuya; Yamaguchi, Junichiro; Itami, Kenichiro.

In: Tetrahedron, Vol. 68, No. 37, 16.09.2012, p. 7605-7612.

Research output: Contribution to journalArticle

Hattori, K, Yamaguchi, K, Yamaguchi, J & Itami, K 2012, 'Pd- and Cu-catalyzed C-H arylation of indazoles', Tetrahedron, vol. 68, no. 37, pp. 7605-7612. https://doi.org/10.1016/j.tet.2012.05.091
Hattori, Keika ; Yamaguchi, Kazuya ; Yamaguchi, Junichiro ; Itami, Kenichiro. / Pd- and Cu-catalyzed C-H arylation of indazoles. In: Tetrahedron. 2012 ; Vol. 68, No. 37. pp. 7605-7612.
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