Pd-Catalyzed Denitrative Intramolecular C-H Arylation

Kitty K. Asahara, Toshimasa Okita, Ami N. Saito, Kei Muto, Yoshiaki Nakao, Junichiro Yamaguchi*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

31 Citations (Scopus)


A Pd-catalyzed intramolecular C-H arylation of nitroarenes has been developed. Nitroarenes bearing tethered aryl groups at the ortho-position can be readily prepared in one step from 2-halonitroarenes by a nucleophilic aromatic substitution (SNAr). Under Pd/BrettPhos catalysis, activations of the C-NO2 bond as well as the C-H bond on arenes generated the corresponding biaryl linkage in moderate to excellent yields.

Original languageEnglish
Pages (from-to)4721-4724
Number of pages4
JournalOrganic Letters
Issue number12
Publication statusPublished - 2019 Jun 21

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry


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