Pd-Catalyzed Denitrative Intramolecular C-H Arylation

Kitty K. Asahara, Toshimasa Okita, Ami N. Saito, Kei Muto, Yoshiaki Nakao, Junichiro Yamaguchi

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

A Pd-catalyzed intramolecular C-H arylation of nitroarenes has been developed. Nitroarenes bearing tethered aryl groups at the ortho-position can be readily prepared in one step from 2-halonitroarenes by a nucleophilic aromatic substitution (SNAr). Under Pd/BrettPhos catalysis, activations of the C-NO2 bond as well as the C-H bond on arenes generated the corresponding biaryl linkage in moderate to excellent yields.

Original languageEnglish
Pages (from-to)4721-4724
Number of pages4
JournalOrganic Letters
Volume21
Issue number12
DOIs
Publication statusPublished - 2019 Jun 21

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Bearings (structural)
Catalysis
linkages
catalysis
Substitution reactions
Chemical activation
activation
substitutes

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

Cite this

Pd-Catalyzed Denitrative Intramolecular C-H Arylation. / Asahara, Kitty K.; Okita, Toshimasa; Saito, Ami N.; Muto, Kei; Nakao, Yoshiaki; Yamaguchi, Junichiro.

In: Organic Letters, Vol. 21, No. 12, 21.06.2019, p. 4721-4724.

Research output: Contribution to journalArticle

Asahara, Kitty K. ; Okita, Toshimasa ; Saito, Ami N. ; Muto, Kei ; Nakao, Yoshiaki ; Yamaguchi, Junichiro. / Pd-Catalyzed Denitrative Intramolecular C-H Arylation. In: Organic Letters. 2019 ; Vol. 21, No. 12. pp. 4721-4724.
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