Pd-catalyzed reductive cleavage of alkyl aryl sulfides with triethylsilane that is accelerated by trialkylsilyl chloride

Takehiko Matsumura, Takashi Niwa, Masahisa Nakada

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26 Citations (Scopus)


The palladium-catalyzed reductive cleavage of alkyl aryl sulfides to afford the corresponding arenes in high yield, which is both accelerated and exhibits increased functional group selectivity in the presence of TMSCl, is described. This ligand-free reaction features mild conditions, easy operation, use of readily available reagents, and high functional group selectivity.

Original languageEnglish
Pages (from-to)4313-4316
Number of pages4
JournalTetrahedron Letters
Issue number33
Publication statusPublished - 2012 Aug 15



  • Alkyl aryl sulfide
  • Pd-catalyzed
  • Reductive cleavage
  • Trialkylsilyl chloride
  • Triethylsilane

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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