Pd-catalyzed reductive cleavage of alkyl aryl sulfides with triethylsilane that is accelerated by trialkylsilyl chloride

Takehiko Matsumura, Takashi Niwa, Masahisa Nakada

    Research output: Contribution to journalArticle

    21 Citations (Scopus)

    Abstract

    The palladium-catalyzed reductive cleavage of alkyl aryl sulfides to afford the corresponding arenes in high yield, which is both accelerated and exhibits increased functional group selectivity in the presence of TMSCl, is described. This ligand-free reaction features mild conditions, easy operation, use of readily available reagents, and high functional group selectivity.

    Original languageEnglish
    Pages (from-to)4313-4316
    Number of pages4
    JournalTetrahedron Letters
    Volume53
    Issue number33
    DOIs
    Publication statusPublished - 2012 Aug 15

    Fingerprint

    Palladium
    Sulfides
    Functional groups
    Chlorides
    Ligands
    triethylsilane

    Keywords

    • Alkyl aryl sulfide
    • Pd-catalyzed
    • Reductive cleavage
    • Trialkylsilyl chloride
    • Triethylsilane

    ASJC Scopus subject areas

    • Biochemistry
    • Organic Chemistry
    • Drug Discovery

    Cite this

    Pd-catalyzed reductive cleavage of alkyl aryl sulfides with triethylsilane that is accelerated by trialkylsilyl chloride. / Matsumura, Takehiko; Niwa, Takashi; Nakada, Masahisa.

    In: Tetrahedron Letters, Vol. 53, No. 33, 15.08.2012, p. 4313-4316.

    Research output: Contribution to journalArticle

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