PEDOT

gelatin composites mediate brain endothelial cell adhesion

Manuelle Bongo, Orawan Winther-Jensen, Scott Himmelberger, Xenofon Strakosas, Marc Ramuz, Adel Hama, Eleni Stavrinidou, George G. Malliaras, Alberto Salleo, Bjorn Winther Jensen, Roisin M. Owens

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Conducting polymers (CPs) are increasingly being used to interface with cells for applications in both bioelectronics and tissue engineering. To facilitate this interaction, cells need to adhere and grow on the CP surface. Extracellular matrix components are usually necessary to support or enhance cell attachment and growth on polymer substrates. Here we show the preparation of PEDOT(TOS):gelatin composites as a new biocompatible substrate for use in tissue engineering. Gelatin, a derivative of the extracellular matrix protein collagen, was incorporated into poly(3,4 ethylenedioxythiophene)-tosylate (PEDOT(TOS)) films via vapour phase polymerisation (VPP) without changing the electrochemical properties of the CP. Further, gelatin, incorporated into the PEDOT(TOS) film, was found to specifically support bovine brain capillary endothelial cell adhesion and growth, indicating that the functionality of the biomolecule was maintained. The biocompatibility of the composite films was demonstrated indicating the significant future potential of biocomposites of this type for use in promoting cell adhesion in electrically active materials for tissue engineering.

Original languageEnglish
Pages (from-to)3860-3867
Number of pages8
JournalJournal of Materials Chemistry B
Volume1
Issue number31
DOIs
Publication statusPublished - 2013 Aug 21
Externally publishedYes

Fingerprint

Cell adhesion
Endothelial cells
Conducting polymers
Gelatin
Tissue engineering
Cell Adhesion
Brain
Polymers
Tissue Engineering
Endothelial Cells
Composite materials
Extracellular Matrix Proteins
Cell growth
Biomolecules
Composite films
Substrates
Electrochemical properties
Biocompatibility
Collagen
Growth

ASJC Scopus subject areas

  • Chemistry(all)
  • Biomedical Engineering
  • Medicine(all)
  • Materials Science(all)

Cite this

Bongo, M., Winther-Jensen, O., Himmelberger, S., Strakosas, X., Ramuz, M., Hama, A., ... Owens, R. M. (2013). PEDOT: gelatin composites mediate brain endothelial cell adhesion. Journal of Materials Chemistry B, 1(31), 3860-3867. https://doi.org/10.1039/c3tb20374c

PEDOT : gelatin composites mediate brain endothelial cell adhesion. / Bongo, Manuelle; Winther-Jensen, Orawan; Himmelberger, Scott; Strakosas, Xenofon; Ramuz, Marc; Hama, Adel; Stavrinidou, Eleni; Malliaras, George G.; Salleo, Alberto; Winther Jensen, Bjorn; Owens, Roisin M.

In: Journal of Materials Chemistry B, Vol. 1, No. 31, 21.08.2013, p. 3860-3867.

Research output: Contribution to journalArticle

Bongo, M, Winther-Jensen, O, Himmelberger, S, Strakosas, X, Ramuz, M, Hama, A, Stavrinidou, E, Malliaras, GG, Salleo, A, Winther Jensen, B & Owens, RM 2013, 'PEDOT: gelatin composites mediate brain endothelial cell adhesion', Journal of Materials Chemistry B, vol. 1, no. 31, pp. 3860-3867. https://doi.org/10.1039/c3tb20374c
Bongo M, Winther-Jensen O, Himmelberger S, Strakosas X, Ramuz M, Hama A et al. PEDOT: gelatin composites mediate brain endothelial cell adhesion. Journal of Materials Chemistry B. 2013 Aug 21;1(31):3860-3867. https://doi.org/10.1039/c3tb20374c
Bongo, Manuelle ; Winther-Jensen, Orawan ; Himmelberger, Scott ; Strakosas, Xenofon ; Ramuz, Marc ; Hama, Adel ; Stavrinidou, Eleni ; Malliaras, George G. ; Salleo, Alberto ; Winther Jensen, Bjorn ; Owens, Roisin M. / PEDOT : gelatin composites mediate brain endothelial cell adhesion. In: Journal of Materials Chemistry B. 2013 ; Vol. 1, No. 31. pp. 3860-3867.
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