PEDOT: gelatin composites mediate brain endothelial cell adhesion

Manuelle Bongo, Orawan Winther-Jensen, Scott Himmelberger, Xenofon Strakosas, Marc Ramuz, Adel Hama, Eleni Stavrinidou, George G. Malliaras, Alberto Salleo, Bjorn Winther Jensen, Roisin M. Owens

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Conducting polymers (CPs) are increasingly being used to interface with cells for applications in both bioelectronics and tissue engineering. To facilitate this interaction, cells need to adhere and grow on the CP surface. Extracellular matrix components are usually necessary to support or enhance cell attachment and growth on polymer substrates. Here we show the preparation of PEDOT(TOS):gelatin composites as a new biocompatible substrate for use in tissue engineering. Gelatin, a derivative of the extracellular matrix protein collagen, was incorporated into poly(3,4 ethylenedioxythiophene)-tosylate (PEDOT(TOS)) films via vapour phase polymerisation (VPP) without changing the electrochemical properties of the CP. Further, gelatin, incorporated into the PEDOT(TOS) film, was found to specifically support bovine brain capillary endothelial cell adhesion and growth, indicating that the functionality of the biomolecule was maintained. The biocompatibility of the composite films was demonstrated indicating the significant future potential of biocomposites of this type for use in promoting cell adhesion in electrically active materials for tissue engineering.

Original languageEnglish
Pages (from-to)3860-3867
Number of pages8
JournalJournal of Materials Chemistry B
Volume1
Issue number31
DOIs
Publication statusPublished - 2013 Aug 21
Externally publishedYes

ASJC Scopus subject areas

  • Chemistry(all)
  • Biomedical Engineering
  • Medicine(all)
  • Materials Science(all)

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  • Cite this

    Bongo, M., Winther-Jensen, O., Himmelberger, S., Strakosas, X., Ramuz, M., Hama, A., Stavrinidou, E., Malliaras, G. G., Salleo, A., Winther Jensen, B., & Owens, R. M. (2013). PEDOT: gelatin composites mediate brain endothelial cell adhesion. Journal of Materials Chemistry B, 1(31), 3860-3867. https://doi.org/10.1039/c3tb20374c