Pentraxin 3 production in the adipose tissue and the skeletal muscle in diabetic-obese mice

Asako Miyaki, Youngju Choi, Seiji Maeda

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)

Abstract

Inflammation has been shown to promote obesity-induced insulin resistance. Although pentraxin (PTX) 3 is known as an anti-inflammatory factor, the effect of PTX3 on insulin sensitivity has not yet been elucidated. The aim of this study is to investigate a part of the role of PTX3 on insulin sensitivity. The authors studied the PTX3 and glucose transport protein expression levels in epididymal adipose tissue and soleus muscles of male diabetic-obese [Tsumura Suzuki obese-diabetic (TSOD)] and lean control mice. The levels of PTX3 in both skeletal muscle and adipose tissue were significantly lower in TSOD mice than in controls, and there was a significant positive correlation between them. They observed a significant positive correlation between PTX3 and glucose transport protein 4 levels in skeletal muscle. This study suggests that PTX3 may play a part of role as promoting insulin sensitivity of skeletal muscle in TSOD mice.

Original languageEnglish
Pages (from-to)228-233
Number of pages6
JournalAmerican Journal of the Medical Sciences
Volume347
Issue number3
DOIs
Publication statusPublished - 2014 Mar
Externally publishedYes

Keywords

  • Diabetes mellitus
  • GLUT4
  • Inflammation
  • Obesity

ASJC Scopus subject areas

  • Medicine(all)

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