Peptide and protein pheromones in amphibians

Sakaé Kikuyama, Kazutoshi Yamamoto, Takeo Iwata, Fumiyo Toyoda

    Research output: Contribution to journalArticle

    55 Citations (Scopus)

    Abstract

    Purification, characterization and biological activity of urodele and anuran sex-pheromones were reviewed. Female-attracting pheromones obtained from the abdominal gland of Cynops pyrrhogaster and C. ensicauda males are peptides consisting of 10 amino acid residues being designated sodefrin and silefrin, respectively. Each pheromone attracted only conspecific females. Molecular cloning of cDNAs encoding sodefrin and silefrin revealed that both are generated from precursor proteins. Synthesis of these pheromones is regulated by prolactin (PRL) and androgen. Responsiveness of the female vomeronasal epithelium to sodefrin is enhanced by PRL and estrogen. The submandibular gland of the male terrestrial salamander, Plethodon jardani secretes a 22-kD proteinaceous pheromone that enhances female receptivity. It was revealed that every salamander synthesizes multiple isoforms of this pheromone, Plethodontid receptivity factor. The magnificent tree frog, Litoria splendida breed in an aquatic environment. The skin glands of the male secrete a female-attracting peptide pheromone, splendipherin, comprising 25 amino acid residues. The significance of the structure of the amphibian sex-pheromone as peptide and protein is discussed in terms of their species specificity.

    Original languageEnglish
    Pages (from-to)69-74
    Number of pages6
    JournalComparative Biochemistry and Physiology - B Biochemistry and Molecular Biology
    Volume132
    Issue number1
    DOIs
    Publication statusPublished - 2002

    Fingerprint

    sodefrin
    Pheromones
    Amphibians
    Peptides
    Sex Attractants
    Urodela
    Proteins
    Prolactin
    Species Specificity
    Amino Acids
    Protein Precursors
    Submandibular Gland
    Cloning
    Molecular Cloning
    Bioactivity
    Anura
    Androgens
    Purification
    Skin
    Protein Isoforms

    Keywords

    • Abdominal gland
    • Courtship behavior
    • Frog
    • Mating behavior
    • Newt
    • Salamander
    • Sex-pheromone
    • Skin gland

    ASJC Scopus subject areas

    • Biochemistry
    • Physiology

    Cite this

    Peptide and protein pheromones in amphibians. / Kikuyama, Sakaé; Yamamoto, Kazutoshi; Iwata, Takeo; Toyoda, Fumiyo.

    In: Comparative Biochemistry and Physiology - B Biochemistry and Molecular Biology, Vol. 132, No. 1, 2002, p. 69-74.

    Research output: Contribution to journalArticle

    Kikuyama, Sakaé ; Yamamoto, Kazutoshi ; Iwata, Takeo ; Toyoda, Fumiyo. / Peptide and protein pheromones in amphibians. In: Comparative Biochemistry and Physiology - B Biochemistry and Molecular Biology. 2002 ; Vol. 132, No. 1. pp. 69-74.
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