Perinatal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin alters activity-dependent expression of BDNF mRNA in the neocortex and male rat sexual behavior in adulthood

Masaki Kakeyama, Hideko Sone, Yuichi Miyabara, Chiharu Tohyama

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Dioxin and its related compounds are suspected to cause neurological and nueroendocrinological disruption in human and laboratory animal offspring upon in utero and lactational exposure during growth and development. We tested the hypothesis by utilizing Long-Evans Hooded rats that perinatal exposure to dioxins affects the neocortical function and expression of sexual behavior in adulthood. In the sexual behavior test, perinatal exposure to TCDD significantly reduced the number of mounts and intromissions. The mRNA semi-quantification in in situ hybridization showed that the mating stimulus in control males induced c-fos mRNA expression in the preoptic area (POA) and the brain derived neurotrophic factor (BDNF) mRNA upregulation in the frontal cortex. In contrast, perinatal exposure to TCDD lowered the upregulation of BDNF mRNA in the frontal cortex but not that of c-fos mRNA in the POA. The volume of the sexually dimorphic nucleus of the preoptic area (SDN-POA) was not affected. The results suggest that perinatal TCDD affects the neocortical function independently from the brain sexual differentiation and alters the expression of sexual behavior.

Original languageEnglish
Pages (from-to)207-217
Number of pages11
JournalNeuroToxicology
Volume24
Issue number2
DOIs
Publication statusPublished - 2003 Mar
Externally publishedYes

Fingerprint

Neocortex
Brain-Derived Neurotrophic Factor
Sexual Behavior
Rats
Preoptic Area
Messenger RNA
Dioxins
Frontal Lobe
Up-Regulation
Long Evans Rats
Sex Differentiation
Laboratory Animals
Growth and Development
In Situ Hybridization
Brain
Animals
Polychlorinated Dibenzodioxins
1,4-dioxin

Keywords

  • 2,3,7,8-Tetrachlorodibenzo-p-dioxin
  • BDNF
  • C-fos
  • Frontal cortex
  • Preoptic area
  • Sexual behavior

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Neuroscience(all)
  • Toxicology

Cite this

Perinatal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin alters activity-dependent expression of BDNF mRNA in the neocortex and male rat sexual behavior in adulthood. / Kakeyama, Masaki; Sone, Hideko; Miyabara, Yuichi; Tohyama, Chiharu.

In: NeuroToxicology, Vol. 24, No. 2, 03.2003, p. 207-217.

Research output: Contribution to journalArticle

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