Periosteum-mimetic structures made from freestanding microgrooved nanosheets

Xuetao Shi, Toshinori Fujie, Akihiro Saito, Shinji Takeoka, Ying Hou, Yiwei Shu, Mingwei Chen, Hongkai Wu, Ali Khademhosseini

    Research output: Contribution to journalArticle

    44 Citations (Scopus)


    A "sticker-like" PLGA nanosheet with microgrooved patterns is developed through a facile combination of spin coating and micropatterning techniques. The resulting microgrooved PLGA nanosheets can be physically adhered on flat or porous surfaces with excellent stability in aqueous environments and can harness the spatial arrangements of cells, which make it a promising candidate for generating biomimic periosteum for bone regenerative applications.

    Original languageEnglish
    Pages (from-to)3290-3296
    Number of pages7
    JournalAdvanced Materials
    Issue number20
    Publication statusPublished - 2014 May 28



    • adhesiveness
    • bone repair
    • micropattern
    • nanosheet
    • periosteum

    ASJC Scopus subject areas

    • Materials Science(all)
    • Mechanics of Materials
    • Mechanical Engineering

    Cite this

    Shi, X., Fujie, T., Saito, A., Takeoka, S., Hou, Y., Shu, Y., Chen, M., Wu, H., & Khademhosseini, A. (2014). Periosteum-mimetic structures made from freestanding microgrooved nanosheets. Advanced Materials, 26(20), 3290-3296.