Peripheral non-small cell lung cancers 2.0 cm or less in diameter: Proposed criteria for limited pulmonary resection based upon clinicopathological presentation

Chimori Konaka, Norihiko Ikeda, Toshimiysu Hiyoshi, Ko Tsuji, Takashi Hirano, Norihiko Kawate, Yoshiro Ebihara, Harubumi Kato

Research output: Contribution to journalArticle

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Abstract

Clinical features of peripheral non-small cell lung cancer 2.0 cm or less were retrospectively analyzed. Nodal status and prognosis in relation to tumor diameter and histologic type were investigated in 171 consecutive patients with peripheral clinical T1N0M0 non-small cell lung carcinomas 2 cm or less in diameter and who had undergone surgical resection between 1976 and 1997. Of the 171 patients, 136 had adenocarcinoma, 27 had squamous cell carcinoma, four had large cell carcinoma, three had carcinoid and one had adeno-squamous carcinoma. There was no statistically significant difference in the incidence of stage I cases between adenocarcinoma and squamous cell carcinoma. Lymph node involvement was recognized in 30 (17.5%) patients: ten (5.8%) at N1 nodes and 20 (11.7%) at N2 nodes. Lymph node metastasis was significantly more common in tumors 1.5-2.0 cm in diameter (22%) than in those 1.5 cm or less in diameter (14.0%, P=0.0490). There was no lymph node metastasis in tumors 1.0 cm or less in diameter. The 5-year survival rates cases with or without lymph node involvement were 63.3 and 75.3%, respectively, showing significant difference (P=0.0338). The result of the present study suggested that systematic mediastinal and hilar lymph node dissection is necessary even for cases with tumor diameter less than 2 cm. However, if the tumor is within 1.0 cm in diameter, mediastinal lymph node dissection might be dispensable; therefore, these cases are good candidates for video-assisted lobectomy. Copyright (C) 1998 Elsevier Science Ireland Ltd.

Original languageEnglish
Pages (from-to)185-191
Number of pages7
JournalLung Cancer
Volume21
Issue number3
DOIs
Publication statusPublished - 1998 Sep 1
Externally publishedYes

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Non-Small Cell Lung Carcinoma
Lung
Lymph Nodes
Squamous Cell Carcinoma
Neoplasms
Lymph Node Excision
Adenocarcinoma
Neoplasm Metastasis
Large Cell Carcinoma
Carcinoid Tumor
Survival Rate
Incidence

Keywords

  • Limited operation
  • Lymph node metastasis
  • Small peripheral lung cancer
  • Video-assisted thoracic surgery (VATS)

ASJC Scopus subject areas

  • Oncology

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Peripheral non-small cell lung cancers 2.0 cm or less in diameter : Proposed criteria for limited pulmonary resection based upon clinicopathological presentation. / Konaka, Chimori; Ikeda, Norihiko; Hiyoshi, Toshimiysu; Tsuji, Ko; Hirano, Takashi; Kawate, Norihiko; Ebihara, Yoshiro; Kato, Harubumi.

In: Lung Cancer, Vol. 21, No. 3, 01.09.1998, p. 185-191.

Research output: Contribution to journalArticle

Konaka, Chimori ; Ikeda, Norihiko ; Hiyoshi, Toshimiysu ; Tsuji, Ko ; Hirano, Takashi ; Kawate, Norihiko ; Ebihara, Yoshiro ; Kato, Harubumi. / Peripheral non-small cell lung cancers 2.0 cm or less in diameter : Proposed criteria for limited pulmonary resection based upon clinicopathological presentation. In: Lung Cancer. 1998 ; Vol. 21, No. 3. pp. 185-191.
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