PGLN: A newly identified amino phosphoglycolipid species in Thermus thermophilus HB8

Naoki Nemoto*, Masahiko Kawaguchi, Kei Yura, Haruo Shimada, Yoshitaka Bessho

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Thermus thermophilus has several minor lipid molecules with structures that have not been described yet. In this study, we identified a new lipid molecule in T. thermophilus HB8 with an amino group at the polar head, by detecting lipid spots with HPTLC and mass spectrometry. The structure of the lipid resembles an amino sugar phospholipid, except for the glucosamine that lacks an acetyl group. We named this amino phosphoglycolipid PGLN, and proposed its synthetic pathway from a precursor, phosphatidyl-glyceric alkylamine. The primary amine structure of PGLN may contribute to high temperature adaptation through electrostatic interactions between the head groups.

Original languageEnglish
Article number101377
JournalBiochemistry and Biophysics Reports
Volume32
DOIs
Publication statusPublished - 2022 Dec

Keywords

  • Amino phospholipid
  • Glucosamine
  • Glycolipid
  • Phospholipid synthetic pathway
  • Polarlipid
  • Thermophiles

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry

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