pH-Sensitive liposome retaining Fe-porphyrin as SOD mimic for novel anticancer drug delivery system

Hiroyoshi Kawakami, Kazue Hiraka, Miho Tamai, Aiko Horiuchi, Akihiko Ogata, Tomomi Hatsugai, Aritomo Yamaguchi, Kenichi Oyaizu, Makoto Yuasa

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

In this article the novel design of an anticancer drug delivery system is reported based on a pH-sensitive liposome retaining the Fe-porphyrin as a superoxide dismutase(SOD) mimic. The liposomes contained cationic/ anionic lipid combinations and were composed of Fe-porphyrin, L-α-phosphatidylcholine (DMPC), dimethylditetradecylammonium bromide (DTDAB), sodispdum oleate (OANa), and Tween-80. The size of the liposome was approximately 30 nm. The EC50 value (the effective concentration of compound required to produce a 50% lethal dose against cells) of the liposome was found to be significantly smaller than that of cisplatin as the control drug, suggesting that the liposome showed a high cytotoxicity toward the cancer cells. This is due to the fact that the pH-sensitive liposome rapidly corresponds to the acidic environments of the endosomes and is unstable, and the Fe-porphyrin is delivered into the cytosol. This result suggests that O2 - may be useful as a target molecule to induce the selective death of cancer cells and that a pH-sensitive liposome retaining Fe-porphyrin as an SOD mimic is a new class of anticancer agent.

Original languageEnglish
Pages (from-to)82-87
Number of pages6
JournalPolymers for Advanced Technologies
Volume18
Issue number1
DOIs
Publication statusPublished - 2007 Jan
Externally publishedYes

Fingerprint

Liposomes
Porphyrins
Superoxide Dismutase
Cells
Dimyristoylphosphatidylcholine
Polysorbates
Oleic Acid
Cytotoxicity
Drug Delivery Systems
Phosphatidylcholines
Antineoplastic Agents
Lipids
Cisplatin
Molecules
Pharmaceutical Preparations

Keywords

  • Drug delivery systems
  • Fe-porphyrin
  • Nanoparticles
  • pH-Sensitive liposome

ASJC Scopus subject areas

  • Polymers and Plastics

Cite this

Kawakami, H., Hiraka, K., Tamai, M., Horiuchi, A., Ogata, A., Hatsugai, T., ... Yuasa, M. (2007). pH-Sensitive liposome retaining Fe-porphyrin as SOD mimic for novel anticancer drug delivery system. Polymers for Advanced Technologies, 18(1), 82-87. https://doi.org/10.1002/pat.855

pH-Sensitive liposome retaining Fe-porphyrin as SOD mimic for novel anticancer drug delivery system. / Kawakami, Hiroyoshi; Hiraka, Kazue; Tamai, Miho; Horiuchi, Aiko; Ogata, Akihiko; Hatsugai, Tomomi; Yamaguchi, Aritomo; Oyaizu, Kenichi; Yuasa, Makoto.

In: Polymers for Advanced Technologies, Vol. 18, No. 1, 01.2007, p. 82-87.

Research output: Contribution to journalArticle

Kawakami, H, Hiraka, K, Tamai, M, Horiuchi, A, Ogata, A, Hatsugai, T, Yamaguchi, A, Oyaizu, K & Yuasa, M 2007, 'pH-Sensitive liposome retaining Fe-porphyrin as SOD mimic for novel anticancer drug delivery system', Polymers for Advanced Technologies, vol. 18, no. 1, pp. 82-87. https://doi.org/10.1002/pat.855
Kawakami, Hiroyoshi ; Hiraka, Kazue ; Tamai, Miho ; Horiuchi, Aiko ; Ogata, Akihiko ; Hatsugai, Tomomi ; Yamaguchi, Aritomo ; Oyaizu, Kenichi ; Yuasa, Makoto. / pH-Sensitive liposome retaining Fe-porphyrin as SOD mimic for novel anticancer drug delivery system. In: Polymers for Advanced Technologies. 2007 ; Vol. 18, No. 1. pp. 82-87.
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