Pharmacokinetics properties of surface-modified vesicles

Keitaro Sou, Beth Coins, William T. Phillips, Shinji Takeoka, Eishun Tsuchida

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Abstract

    Phospholipid vesicles, also called liposome, are potent carriers of various drugs and offer a drug targeting system into specific organs, tissues, or cells, to minimize the drug administration dose and improve the therapeutic safety. Recently, we have found that phospholipid vesicle containing an anionic amphiphile; 1,5-dihexadecyl-L-glutamate-N-succinic acid (Suc-2C 16) and polyethylene glycol)-lipid (PEG-DSPE) are mainly up taken by rabbit bone marrow at a small injection dose (15 mg/kg b.w.). At 24 h after intravenous injection of 99m-technetimu ( 99mTc)-labeled vesicles in rabbit, biodistribution data clearly indicated that the component of Suc-2C 16 induced the significant affinity to bone marrow in comparison with control vesicles, which do not have Suc-2C 16. Further incorporation of as little as 0.6 mol% of PEG-DSPE passively enhanced the distribution of Suc-Ve into bone marrow inhibiting the liver uptake, and this formulation was distributed in the bone marrow over the whole body, reaching to 70% of the injected dose by 6 h after injection.

    Original languageEnglish
    Title of host publicationPolymer Preprints, Japan
    Pages3046-3047
    Number of pages2
    Volume54
    Edition2
    Publication statusPublished - 2005
    Event54th SPSJ Symposium on Macromolecules - Yamagata
    Duration: 2005 Sep 202005 Sep 22

    Other

    Other54th SPSJ Symposium on Macromolecules
    CityYamagata
    Period05/9/2005/9/22

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    Keywords

    • Bone marrow
    • Carrier
    • Pharmacokinetics
    • Phospholipid vesicles
    • Poly (ethylene glycol)
    • Surface modification

    ASJC Scopus subject areas

    • Engineering(all)

    Cite this

    Sou, K., Coins, B., Phillips, W. T., Takeoka, S., & Tsuchida, E. (2005). Pharmacokinetics properties of surface-modified vesicles. In Polymer Preprints, Japan (2 ed., Vol. 54, pp. 3046-3047)