Abstract
The 5-HTergic neurons in the mesencephalic raphe nuclei provide a robust projection to the hypothalamic suprachiasmatic nucleus (SCN), the site of a putative neuronal circadian pacemaker. Although it has been suggested that 5-HT neurons may play a role in the circadian timing system, this role has not yet been specified. Prosser et al. (Brain Res., 534 (1990) 336-339) reported that 1 h treatments with quipazine induce robust phase shifts in vitro, and that this effect depends upon the circadian time of treatment. However, quipazine is a non-specific 5-HT agonist. Besides, it is reported that the 5-HT1A agonist, 8-hydroxy-2-(di-n-propylamino)tetraline hydrobromide (8-OH-DPAT) affected a circadian rhythm of hamster wheel-running activity. In the present study we investigated whether the 5-HT1A agonist 8-OH-DPAT can reset the phase of the SCN clock when it is isolated in vitro. The present results show that 1 h treatments with 8-OH-DPAT induce robust phase advances in vitro when it was administered during the subjective day. This result suggests that 5HT1A receptor functioning may play a role in modulating the phase of SCN clock, especially during the subjective day.
| Original language | English |
|---|---|
| Pages (from-to) | 353-356 |
| Number of pages | 4 |
| Journal | Brain Research |
| Volume | 582 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 1992 Jun 12 |
| Externally published | Yes |
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Keywords
- 5-Hydroxytryptamine
- 8-OH-DPAT
- Circadian rhythm
- Serotonin 5-HT
- Suprachiasmatic nucleus
ASJC Scopus subject areas
- Developmental Biology
- Molecular Biology
- Clinical Neurology
- Neuroscience(all)
Cite this
Phase-resetting efect of 8-OH-DPAT, a serotonin1A receptor agonist, on the circadian rhythm of firing rate in the rat suprachiasmatic nuclei in vitro. / Shibata, Shigenobu; Tsuneyoshi, Atsuko; Hamada, Toshiyuki; Tominaga, Keiko; Watanabe, Shigenori.
In: Brain Research, Vol. 582, No. 2, 12.06.1992, p. 353-356.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Phase-resetting efect of 8-OH-DPAT, a serotonin1A receptor agonist, on the circadian rhythm of firing rate in the rat suprachiasmatic nuclei in vitro
AU - Shibata, Shigenobu
AU - Tsuneyoshi, Atsuko
AU - Hamada, Toshiyuki
AU - Tominaga, Keiko
AU - Watanabe, Shigenori
PY - 1992/6/12
Y1 - 1992/6/12
N2 - The 5-HTergic neurons in the mesencephalic raphe nuclei provide a robust projection to the hypothalamic suprachiasmatic nucleus (SCN), the site of a putative neuronal circadian pacemaker. Although it has been suggested that 5-HT neurons may play a role in the circadian timing system, this role has not yet been specified. Prosser et al. (Brain Res., 534 (1990) 336-339) reported that 1 h treatments with quipazine induce robust phase shifts in vitro, and that this effect depends upon the circadian time of treatment. However, quipazine is a non-specific 5-HT agonist. Besides, it is reported that the 5-HT1A agonist, 8-hydroxy-2-(di-n-propylamino)tetraline hydrobromide (8-OH-DPAT) affected a circadian rhythm of hamster wheel-running activity. In the present study we investigated whether the 5-HT1A agonist 8-OH-DPAT can reset the phase of the SCN clock when it is isolated in vitro. The present results show that 1 h treatments with 8-OH-DPAT induce robust phase advances in vitro when it was administered during the subjective day. This result suggests that 5HT1A receptor functioning may play a role in modulating the phase of SCN clock, especially during the subjective day.
AB - The 5-HTergic neurons in the mesencephalic raphe nuclei provide a robust projection to the hypothalamic suprachiasmatic nucleus (SCN), the site of a putative neuronal circadian pacemaker. Although it has been suggested that 5-HT neurons may play a role in the circadian timing system, this role has not yet been specified. Prosser et al. (Brain Res., 534 (1990) 336-339) reported that 1 h treatments with quipazine induce robust phase shifts in vitro, and that this effect depends upon the circadian time of treatment. However, quipazine is a non-specific 5-HT agonist. Besides, it is reported that the 5-HT1A agonist, 8-hydroxy-2-(di-n-propylamino)tetraline hydrobromide (8-OH-DPAT) affected a circadian rhythm of hamster wheel-running activity. In the present study we investigated whether the 5-HT1A agonist 8-OH-DPAT can reset the phase of the SCN clock when it is isolated in vitro. The present results show that 1 h treatments with 8-OH-DPAT induce robust phase advances in vitro when it was administered during the subjective day. This result suggests that 5HT1A receptor functioning may play a role in modulating the phase of SCN clock, especially during the subjective day.
KW - 5-Hydroxytryptamine
KW - 8-OH-DPAT
KW - Circadian rhythm
KW - Serotonin 5-HT
KW - Suprachiasmatic nucleus
UR - http://www.scopus.com/inward/record.url?scp=0026695257&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026695257&partnerID=8YFLogxK
U2 - 10.1016/0006-8993(92)90156-4
DO - 10.1016/0006-8993(92)90156-4
M3 - Article
C2 - 1393558
AN - SCOPUS:0026695257
VL - 582
SP - 353
EP - 356
JO - Brain Research
JF - Brain Research
SN - 0006-8993
IS - 2
ER -