Phase-resetting response to (+)8-OH-DPAT, a serotonin 1A/7 receptor agonist, in the mouse in vivo

Kazumasa Horikawa, Shigenobu Shibata

    Research output: Contribution to journalArticle

    41 Citations (Scopus)

    Abstract

    Several lines of evidence indicate that 5-HT neuronal systems may play a critical role for the non-photic entrainment of the rodent circadian clock. Although it is well established that (+)8-hydroxy-2-(di-n-propylamino)tetralin [(+)8-OH-DPAT], a 5-HT 1A/7 receptor agonist, causes a phase-advance of behavioral rhythm in hamsters, little is known whether this agent produces phase shifts of activity rhythm in mice. Therefore, we examined the effect of (+)8-OH-DPAT on the mouse locomotor activity rhythm. Systemic administration of this chemical at mid-subjective daytime induced a clear and dose-dependent phase advance, while there were no significant phase shifts at other times (early-subjective day, late-subjective day, or subjective night). Additionally, (+)8-OH-DPAT accelerated the re-entrainment of mouse behavioral rhythm to a 6-h advanced light-dark cycle. These results suggest that we can use mice for understanding the molecular mechanism of (+)8-OH-DPAT-induced phase shift because of availability of clock gene targeted mice.

    Original languageEnglish
    Pages (from-to)130-134
    Number of pages5
    JournalNeuroscience Letters
    Volume368
    Issue number2
    DOIs
    Publication statusPublished - 2004 Sep 23

    Fingerprint

    8-Hydroxy-2-(di-n-propylamino)tetralin
    Receptor, Serotonin, 5-HT1A
    Circadian Clocks
    Photoperiod
    Locomotion
    Cricetinae
    Rodentia
    Serotonin
    serotonin 7 receptor
    hydroxide ion
    Genes

    Keywords

    • (+)8-OH-DPAT
    • 5-HT receptor
    • Circadian rhythm
    • Mouse
    • Phase shift
    • Serotonin

    ASJC Scopus subject areas

    • Neuroscience(all)

    Cite this

    Phase-resetting response to (+)8-OH-DPAT, a serotonin 1A/7 receptor agonist, in the mouse in vivo. / Horikawa, Kazumasa; Shibata, Shigenobu.

    In: Neuroscience Letters, Vol. 368, No. 2, 23.09.2004, p. 130-134.

    Research output: Contribution to journalArticle

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