Phosphocholine-substituted 5,10,15,20-tetraphenylporphyrinatoiron(II): Oxygen carrier under physiological conditions

Eishun Tsuchida, Hiroyuki Nishide, Makoto Yuasa, Etsuo Hasegawa, Yoh ichi Matsushita, Kiyoshi Eshima

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

A novel and amphiphilic 5,10,15,20-tetraphenylporphyrinatoiron complex substituted with phosphocholine groups, 5,10,15,20-tetra{α,α,α,α-o- [2′,2′-dimethyl-20′-(2″-trimethylammonioethyl phosphonatoxy)eicosanamido]phenyl}porphyrinatoiron(II) (lipid-heme), has been synthesized. The lipid-heme formed a stable liposome with a phospholipid. The liposomal lipid-heme reversibly bound oxygen in neutral aqueous media at 37 °C, and its oxygen-binding rate and affinity were similar to those of red blood cells.

Original languageEnglish
Pages (from-to)275-278
Number of pages4
JournalJournal of the Chemical Society, Dalton Transactions
Issue number2
DOIs
Publication statusPublished - 1985

ASJC Scopus subject areas

  • Chemistry(all)

Fingerprint Dive into the research topics of 'Phosphocholine-substituted 5,10,15,20-tetraphenylporphyrinatoiron(II): Oxygen carrier under physiological conditions'. Together they form a unique fingerprint.

  • Cite this