Phosphocholine-substituted 5,10,15,20-tetraphenylporphyrinatoiron(II): Oxygen carrier under physiological conditions

Eishun Tsuchida, Hiroyuki Nishide, Makoto Yuasa, Etsuo Hasegawa, Yoh ichi Matsushita, Kiyoshi Eshima

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

A novel and amphiphilic 5,10,15,20-tetraphenylporphyrinatoiron complex substituted with phosphocholine groups, 5,10,15,20-tetra{α,α,α,α-o- [2′,2′-dimethyl-20′-(2″-trimethylammonioethyl phosphonatoxy)eicosanamido]phenyl}porphyrinatoiron(II) (lipid-heme), has been synthesized. The lipid-heme formed a stable liposome with a phospholipid. The liposomal lipid-heme reversibly bound oxygen in neutral aqueous media at 37 °C, and its oxygen-binding rate and affinity were similar to those of red blood cells.

Original languageEnglish
Pages (from-to)275-278
Number of pages4
JournalJournal of the Chemical Society, Dalton Transactions
Issue number2
DOIs
Publication statusPublished - 1985

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Phosphorylcholine
Heme
Oxygen
Lipids
Liposomes
Phospholipids
Blood
Cells

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Phosphocholine-substituted 5,10,15,20-tetraphenylporphyrinatoiron(II) : Oxygen carrier under physiological conditions. / Tsuchida, Eishun; Nishide, Hiroyuki; Yuasa, Makoto; Hasegawa, Etsuo; Matsushita, Yoh ichi; Eshima, Kiyoshi.

In: Journal of the Chemical Society, Dalton Transactions, No. 2, 1985, p. 275-278.

Research output: Contribution to journalArticle

Tsuchida, Eishun ; Nishide, Hiroyuki ; Yuasa, Makoto ; Hasegawa, Etsuo ; Matsushita, Yoh ichi ; Eshima, Kiyoshi. / Phosphocholine-substituted 5,10,15,20-tetraphenylporphyrinatoiron(II) : Oxygen carrier under physiological conditions. In: Journal of the Chemical Society, Dalton Transactions. 1985 ; No. 2. pp. 275-278.
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