Phosphorylated gelatin to enhance cell adhesion to titanium

Shin Hye Park, Liping Zhu, Seiichi Tada, Sei Obuse, Yasuhiro Yoshida, Mariko Nakamura, Tae Il Son, Satoshi Tsuneda, Yoshihiro Ito

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Abstract

Phosphorylated gelatin was prepared for surface modification of titanium to enhance cell attachment. The modified gelatin was synthesized by coupling gelatin with phosphonobutyric acid with water-soluble carbodiimide. Circular dichroism revealed no significant change in the gelatin as a result of phosphorylation. The binding behavior of phosphorylated gelatin on the titanium surface was observed by quartz crystal microbalance. The modified titanium surface was analyzed by measuring the water contact angle. Enhancement of the attachment of osteoblast cells MC-3T3L1 was observed on the phosphorylated-gelatin-modified titanium. Phosphorylation of gelatin was effective for preparation of a cell-adhesive titanium surface.

Original languageEnglish
Pages (from-to)1616-1619
Number of pages4
JournalPolymer International
Volume63
Issue number9
DOIs
Publication statusPublished - 2014 Sep

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Keywords

  • Cell adhesion
  • Gelatin
  • Phosphorylation
  • Titanium

ASJC Scopus subject areas

  • Polymers and Plastics
  • Organic Chemistry
  • Materials Chemistry

Cite this

Park, S. H., Zhu, L., Tada, S., Obuse, S., Yoshida, Y., Nakamura, M., Son, T. I., Tsuneda, S., & Ito, Y. (2014). Phosphorylated gelatin to enhance cell adhesion to titanium. Polymer International, 63(9), 1616-1619. https://doi.org/10.1002/pi.4647