Photonavigation of cell migration on caged cell-culturing substrates

Jun Nakanishi; Tohru Takarada; Yukiko Kikuchi; Hidekazu Nakyama; Kazuo Yamaguchi; Mizuo Maeda

Photonavigation of cell migration on caged cell-culturing substrates

Jun Nakanishi, Tohru Takarada, Yukiko Kikuchi, Hidekazu Nakyama, Kazuo Yamaguchi, Mizuo Maeda

Research output: Contribution to conference › Paper

Abstract

Cell migration is a fundamental biological activity, which is involved in both physiological and pathological processes, including embryonic development, inflammation, cancer cell migration, and metastasis. In the present study, we have developed a new method for studying the migration of single cells using a "Caged Cell-Culturing Substrate", which we had recently developed. Cells attached onto a single cell array were released from their geometrical confinements by illumination, which switched on migration of the cells onto the illuminated regions. The formation of cell-adhesive regions can be conducted under fluorescence microscopes. The present method will be useful for studying the regulatory mechanism of cell motility.

Original language	English
Number of pages	1
Publication status	Published - 2005 Dec 1
Externally published	Yes
Event	54th SPSJ Annual Meeting 2005 - Yokohama, Japan Duration: 2005 May 25 → 2005 May 27

Conference

Conference	54th SPSJ Annual Meeting 2005
Country	Japan
City	Yokohama
Period	05/5/25 → 05/5/27

Keywords

Caged compounds
Cell adhesion
Cell migration
Cell patterning
Monolayer

ASJC Scopus subject areas

Engineering(all)

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T1 - Photonavigation of cell migration on caged cell-culturing substrates

AU - Nakanishi, Jun

AU - Takarada, Tohru

AU - Kikuchi, Yukiko

AU - Nakyama, Hidekazu

AU - Yamaguchi, Kazuo

AU - Maeda, Mizuo

PY - 2005/12/1

Y1 - 2005/12/1

N2 - Cell migration is a fundamental biological activity, which is involved in both physiological and pathological processes, including embryonic development, inflammation, cancer cell migration, and metastasis. In the present study, we have developed a new method for studying the migration of single cells using a "Caged Cell-Culturing Substrate", which we had recently developed. Cells attached onto a single cell array were released from their geometrical confinements by illumination, which switched on migration of the cells onto the illuminated regions. The formation of cell-adhesive regions can be conducted under fluorescence microscopes. The present method will be useful for studying the regulatory mechanism of cell motility.

AB - Cell migration is a fundamental biological activity, which is involved in both physiological and pathological processes, including embryonic development, inflammation, cancer cell migration, and metastasis. In the present study, we have developed a new method for studying the migration of single cells using a "Caged Cell-Culturing Substrate", which we had recently developed. Cells attached onto a single cell array were released from their geometrical confinements by illumination, which switched on migration of the cells onto the illuminated regions. The formation of cell-adhesive regions can be conducted under fluorescence microscopes. The present method will be useful for studying the regulatory mechanism of cell motility.

KW - Caged compounds

KW - Cell adhesion

KW - Cell migration

KW - Cell patterning

KW - Monolayer

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