Photonavigation of cell migration on caged cell-culturing substrates

Jun Nakanishi, Tohru Takarada, Yukiko Kikuchi, Hidekazu Nakyama, Kazuo Yamaguchi, Mizuo Maeda

Research output: Contribution to conferencePaper

Abstract

Cell migration is a fundamental biological activity, which is involved in both physiological and pathological processes, including embryonic development, inflammation, cancer cell migration, and metastasis. In the present study, we have developed a new method for studying the migration of single cells using a "Caged Cell-Culturing Substrate", which we had recently developed. Cells attached onto a single cell array were released from their geometrical confinements by illumination, which switched on migration of the cells onto the illuminated regions. The formation of cell-adhesive regions can be conducted under fluorescence microscopes. The present method will be useful for studying the regulatory mechanism of cell motility.

Original languageEnglish
Number of pages1
Publication statusPublished - 2005 Dec 1
Externally publishedYes
Event54th SPSJ Annual Meeting 2005 - Yokohama, Japan
Duration: 2005 May 252005 May 27

Conference

Conference54th SPSJ Annual Meeting 2005
CountryJapan
CityYokohama
Period05/5/2505/5/27

Keywords

  • Caged compounds
  • Cell adhesion
  • Cell migration
  • Cell patterning
  • Monolayer

ASJC Scopus subject areas

  • Engineering(all)

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