Photoreception and circadian clock system of the chicken pineal gland

Toshiyuki Okano, Yoshitaka Fukada

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Chicken pinealocytes contain three major components of the circadian clock system: 1) a self-sustained oscillator, 2) a photic-input pathway to the oscillator, and 3) an overt output represented by the rhythmic production of melatonin. Even under cultured conditions of isolated pineal gland or dissociated pinealocytes, the input-oscillator-output functions are well maintained. Because of these experimental advantages, chicken pineal gland has been one of the best models for the study of the circadian clock system. Since the finding of a pineal-specific photoreceptive molecule, pinopsin, we have characterized the endogenous phototransduction pathway in the pinealocytes. On the other hand, despite the long history of chick pineal research, the molecular mechanism underlying the pineal clock oscillation has been largely unknown. Our recent characterization of the chick pineal clock genes strongly suggests that they constitute a transcription/translation-based autoregulatory feedback loop, which is very similar to that generating circadian rhythmicity in mammalian SCN.

Original languageEnglish
Pages (from-to)72-80
Number of pages9
JournalMicroscopy Research and Technique
Volume53
Issue number1
DOIs
Publication statusPublished - 2001 Apr 1
Externally publishedYes

Fingerprint

pineal gland
pineal body
chickens
Circadian Clocks
Pineal Gland
circadian rhythm
clocks
Clocks
Chickens
chicks
Light Signal Transduction
phototransduction
oscillators
melatonin
Periodicity
Melatonin
translation (genetics)
oscillation
photics
transcription (genetics)

Keywords

  • Circadian rhythm
  • G-protein
  • MAPK
  • Melatonin
  • Pinopsin

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Anatomy
  • Instrumentation

Cite this

Photoreception and circadian clock system of the chicken pineal gland. / Okano, Toshiyuki; Fukada, Yoshitaka.

In: Microscopy Research and Technique, Vol. 53, No. 1, 01.04.2001, p. 72-80.

Research output: Contribution to journalArticle

@article{1bf5555c8ed147eaac4ae26a40241b62,
title = "Photoreception and circadian clock system of the chicken pineal gland",
abstract = "Chicken pinealocytes contain three major components of the circadian clock system: 1) a self-sustained oscillator, 2) a photic-input pathway to the oscillator, and 3) an overt output represented by the rhythmic production of melatonin. Even under cultured conditions of isolated pineal gland or dissociated pinealocytes, the input-oscillator-output functions are well maintained. Because of these experimental advantages, chicken pineal gland has been one of the best models for the study of the circadian clock system. Since the finding of a pineal-specific photoreceptive molecule, pinopsin, we have characterized the endogenous phototransduction pathway in the pinealocytes. On the other hand, despite the long history of chick pineal research, the molecular mechanism underlying the pineal clock oscillation has been largely unknown. Our recent characterization of the chick pineal clock genes strongly suggests that they constitute a transcription/translation-based autoregulatory feedback loop, which is very similar to that generating circadian rhythmicity in mammalian SCN.",
keywords = "Circadian rhythm, G-protein, MAPK, Melatonin, Pinopsin",
author = "Toshiyuki Okano and Yoshitaka Fukada",
year = "2001",
month = "4",
day = "1",
doi = "10.1002/jemt.1070",
language = "English",
volume = "53",
pages = "72--80",
journal = "Microscopy Research and Technique",
issn = "1059-910X",
publisher = "Wiley-Liss Inc.",
number = "1",

}

TY - JOUR

T1 - Photoreception and circadian clock system of the chicken pineal gland

AU - Okano, Toshiyuki

AU - Fukada, Yoshitaka

PY - 2001/4/1

Y1 - 2001/4/1

N2 - Chicken pinealocytes contain three major components of the circadian clock system: 1) a self-sustained oscillator, 2) a photic-input pathway to the oscillator, and 3) an overt output represented by the rhythmic production of melatonin. Even under cultured conditions of isolated pineal gland or dissociated pinealocytes, the input-oscillator-output functions are well maintained. Because of these experimental advantages, chicken pineal gland has been one of the best models for the study of the circadian clock system. Since the finding of a pineal-specific photoreceptive molecule, pinopsin, we have characterized the endogenous phototransduction pathway in the pinealocytes. On the other hand, despite the long history of chick pineal research, the molecular mechanism underlying the pineal clock oscillation has been largely unknown. Our recent characterization of the chick pineal clock genes strongly suggests that they constitute a transcription/translation-based autoregulatory feedback loop, which is very similar to that generating circadian rhythmicity in mammalian SCN.

AB - Chicken pinealocytes contain three major components of the circadian clock system: 1) a self-sustained oscillator, 2) a photic-input pathway to the oscillator, and 3) an overt output represented by the rhythmic production of melatonin. Even under cultured conditions of isolated pineal gland or dissociated pinealocytes, the input-oscillator-output functions are well maintained. Because of these experimental advantages, chicken pineal gland has been one of the best models for the study of the circadian clock system. Since the finding of a pineal-specific photoreceptive molecule, pinopsin, we have characterized the endogenous phototransduction pathway in the pinealocytes. On the other hand, despite the long history of chick pineal research, the molecular mechanism underlying the pineal clock oscillation has been largely unknown. Our recent characterization of the chick pineal clock genes strongly suggests that they constitute a transcription/translation-based autoregulatory feedback loop, which is very similar to that generating circadian rhythmicity in mammalian SCN.

KW - Circadian rhythm

KW - G-protein

KW - MAPK

KW - Melatonin

KW - Pinopsin

UR - http://www.scopus.com/inward/record.url?scp=0035313481&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035313481&partnerID=8YFLogxK

U2 - 10.1002/jemt.1070

DO - 10.1002/jemt.1070

M3 - Article

C2 - 11279672

AN - SCOPUS:0035313481

VL - 53

SP - 72

EP - 80

JO - Microscopy Research and Technique

JF - Microscopy Research and Technique

SN - 1059-910X

IS - 1

ER -