Physical and inflammatory stressors elevate circadian clock gene mPer1 mRNA levels in the paraventricular nucleus of the mouse

Satomi Takahashi, Shin Ichi Yokota, Reiko Hara, Tomoko Kobayashi, Masashi Akiyama, Takahiro Moriya, Shigenobu Shibata

    Research output: Contribution to journalArticle

    75 Citations (Scopus)

    Abstract

    Stress induces secretion of corticosterone through activation of the hypothalamic-pituitary-adrenal axis. This corticosterone secretion is thought to be controlled by a circadian clock in the suprachiasmatic nucleus (SCN). The hypothalamic paraventricular nucleus (PVN) receives convergent information from both stress and the circadian clock. Recent reports demonstrate that mammalian orthologs (Per1, Per2, and Per3) of the Drosophila clock gene Period are expressed in the SCN, PVN, and peripheral tissues. In this experiment, we examined the effect of physical and inflammatory stressors on mPer gene expression in the SCN, PVN, and liver. Forced swimming, immobilization, and lipopolysaccharide injection elevated mPer1 gene expression in the PVN but not in the SCN or liver. A stress-induced increase in mPer1 expression was observed in the corticotropin-releasing factor-positive cells of the PVN; however, the stressors used in this study did not affect mPer2 expression in the PVN, SCN, or liver. The present study suggests that a stress-induced disturbance of circadian corticosterone secretion may be associated with the stress-induced expression of mPer1 mRNA in the PVN.

    Original languageEnglish
    Pages (from-to)4910-4917
    Number of pages8
    JournalEndocrinology
    Volume142
    Issue number11
    DOIs
    Publication statusPublished - 2001

    Fingerprint

    Circadian Clocks
    Paraventricular Hypothalamic Nucleus
    Suprachiasmatic Nucleus
    Messenger RNA
    Genes
    Corticosterone
    Liver
    Gene Expression
    Corticotropin-Releasing Hormone
    Cell Nucleus
    Immobilization
    Drosophila
    Lipopolysaccharides
    Injections

    ASJC Scopus subject areas

    • Endocrinology
    • Endocrinology, Diabetes and Metabolism

    Cite this

    Physical and inflammatory stressors elevate circadian clock gene mPer1 mRNA levels in the paraventricular nucleus of the mouse. / Takahashi, Satomi; Yokota, Shin Ichi; Hara, Reiko; Kobayashi, Tomoko; Akiyama, Masashi; Moriya, Takahiro; Shibata, Shigenobu.

    In: Endocrinology, Vol. 142, No. 11, 2001, p. 4910-4917.

    Research output: Contribution to journalArticle

    Takahashi, Satomi ; Yokota, Shin Ichi ; Hara, Reiko ; Kobayashi, Tomoko ; Akiyama, Masashi ; Moriya, Takahiro ; Shibata, Shigenobu. / Physical and inflammatory stressors elevate circadian clock gene mPer1 mRNA levels in the paraventricular nucleus of the mouse. In: Endocrinology. 2001 ; Vol. 142, No. 11. pp. 4910-4917.
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    AU - Akiyama, Masashi

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