Physics underling Topobiology: Space-time Structure underlying the Morphogenetic Process

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    2 Citations (Scopus)

    Abstract

    Development processes of multi-cellular systems have attracted attention for a long time. One particular aspect of interest is the fusion of the symmetric and asymmetric cell divisions in space. We clarify the physical principle for determining whether asymmetric cell divisions occur in living beings or not. Then, we also reveal the physical reason why the organs such as arms, legs, lungs, vertebrae, and kidneys are left-right symmetric, while the heart and the liver are asymmetric. Next, we examine the temporal aspects underlying the morphogenetic processes. The macroscopic model having six categories of molecules shows that the antagonism between the negative controllers and the positive replication factors induces bifurcations in stem and pluripotent cells at rhythmic intervals comprising about six divisions. This cycle of six divisions, i.e., branching time between periodic bifurcation events, corresponds to the emergence timings of blast cysts, embryos, germ layers, tissues, and organs, which can be observed for about every six cell divisions. Finally, we show that the evolution of negative controllers brings longer non-coding regions in DNA and higher-organisms.

    Original languageEnglish
    Title of host publicationIFMBE Proceedings
    Pages1329-1332
    Number of pages4
    Volume23
    DOIs
    Publication statusPublished - 2009
    Event13th International Conference on Biomedical Engineering, ICBME 2008 -
    Duration: 2008 Dec 32008 Dec 6

    Other

    Other13th International Conference on Biomedical Engineering, ICBME 2008
    Period08/12/308/12/6

    Fingerprint

    Physics
    Cells
    Controllers
    Liver
    DNA
    Fusion reactions
    Tissue
    Molecules

    Keywords

    • Asymmetry
    • Cytofluid dynamic theory
    • Morphogenesis
    • Organs
    • Topobiology

    ASJC Scopus subject areas

    • Biomedical Engineering
    • Bioengineering

    Cite this

    Physics underling Topobiology : Space-time Structure underlying the Morphogenetic Process. / Naitoh, Ken.

    IFMBE Proceedings. Vol. 23 2009. p. 1329-1332.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Naitoh, K 2009, Physics underling Topobiology: Space-time Structure underlying the Morphogenetic Process. in IFMBE Proceedings. vol. 23, pp. 1329-1332, 13th International Conference on Biomedical Engineering, ICBME 2008, 08/12/3. https://doi.org/10.1007/978-3-540-92841-6_327
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