Physiological functions of the giant elastic protein titin in mammalian striated muscle

Norio Fukuda, Henk L. Granzier, Shin'ichi Ishiwata, Satoshi Kurihara

    Research output: Contribution to journalArticle

    67 Citations (Scopus)

    Abstract

    The striated muscle sarcomere contains the third filament comprising the giant elastic protein titin, in addition to thick and thin filaments. Titin is the primary source of nonactomyosin-based passive force in both skeletal and cardiac muscles, within the physiological sarcomere length range. Titin's force repositions the thick filaments in the center of the sarcomere after contraction or stretch and thus maintains sarcomere length and structural integrity. In the heart, titin determines myocardial wall stiffness, thereby regulating ventricular filling. Recent studies have revealed the mechanisms involved in the fine tuning of titin-based passive force via alternative splicing or posttranslational modification. It has also been discovered that titin performs roles that go beyond passive force generation, such as a regulation of the Frank-Starling mechanism of the heart. In this review, we discuss how titin regulates passive and active properties of striated muscle during normal muscle function and during disease.

    Original languageEnglish
    Pages (from-to)151-159
    Number of pages9
    JournalJournal of Physiological Sciences
    Volume58
    Issue number3
    DOIs
    Publication statusPublished - 2008 Jun

    Fingerprint

    Connectin
    Striated Muscle
    Sarcomeres
    Proteins
    Starlings
    Alternative Splicing
    Post Translational Protein Processing
    Myocardium
    Skeletal Muscle
    Muscles

    Keywords

    • Ca
    • Cardiac muscle
    • Connectin
    • Skeletal muscle
    • Skinned muscle

    ASJC Scopus subject areas

    • Physiology

    Cite this

    Physiological functions of the giant elastic protein titin in mammalian striated muscle. / Fukuda, Norio; Granzier, Henk L.; Ishiwata, Shin'ichi; Kurihara, Satoshi.

    In: Journal of Physiological Sciences, Vol. 58, No. 3, 06.2008, p. 151-159.

    Research output: Contribution to journalArticle

    Fukuda, Norio ; Granzier, Henk L. ; Ishiwata, Shin'ichi ; Kurihara, Satoshi. / Physiological functions of the giant elastic protein titin in mammalian striated muscle. In: Journal of Physiological Sciences. 2008 ; Vol. 58, No. 3. pp. 151-159.
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