Piezoelectric Nanoparticle-Assisted Wireless Neuronal Stimulation

Attilio Marino, Satoshi Arai, Yanyan Hou, Edoardo Sinibaldi, Mario Pellegrino, Young Tae Chang, Barbara Mazzolai, Virgilio Mattoli, Madoka Suzuki, Gianni Ciofani

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

Tetragonal barium titanate nanoparticles (BTNPs) have been exploited as nanotransducers owing to their piezoelectric properties, in order to provide indirect electrical stimulation to SH-SY5Y neuron-like cells. Following application of ultrasounds to cells treated with BTNPs, fluorescence imaging of ion dynamics revealed that the synergic stimulation is able to elicit a significant cellular response in terms of calcium and sodium fluxes; moreover, tests with appropriate blockers demonstrated that voltage-gated membrane channels are activated. The hypothesis of piezoelectric stimulation of neuron-like cells was supported by lack of cellular response in the presence of cubic nonpiezoelectric BTNPs, and further corroborated by a simple electroelastic model of a BTNP subjected to ultrasounds, according to which the generated voltage is compatible with the values required for the activation of voltage-sensitive channels.

Original languageEnglish
Pages (from-to)7678-7689
Number of pages12
JournalACS Nano
Volume9
Issue number7
DOIs
Publication statusPublished - 2015 Jul 28

Fingerprint

Barium titanate
stimulation
barium
Nanoparticles
nanoparticles
neurons
Neurons
Electric potential
electric potential
Ultrasonics
cells
Ion Channels
calcium
Calcium
Sodium
Fluorescence
Chemical activation
sodium
activation
Ions

Keywords

  • barium titanate nanoparticles
  • calcium imaging
  • piezoelectricity
  • SH-SY5Y cells
  • ultrasounds

ASJC Scopus subject areas

  • Engineering(all)
  • Materials Science(all)
  • Physics and Astronomy(all)

Cite this

Marino, A., Arai, S., Hou, Y., Sinibaldi, E., Pellegrino, M., Chang, Y. T., ... Ciofani, G. (2015). Piezoelectric Nanoparticle-Assisted Wireless Neuronal Stimulation. ACS Nano, 9(7), 7678-7689. https://doi.org/10.1021/acsnano.5b03162

Piezoelectric Nanoparticle-Assisted Wireless Neuronal Stimulation. / Marino, Attilio; Arai, Satoshi; Hou, Yanyan; Sinibaldi, Edoardo; Pellegrino, Mario; Chang, Young Tae; Mazzolai, Barbara; Mattoli, Virgilio; Suzuki, Madoka; Ciofani, Gianni.

In: ACS Nano, Vol. 9, No. 7, 28.07.2015, p. 7678-7689.

Research output: Contribution to journalArticle

Marino, A, Arai, S, Hou, Y, Sinibaldi, E, Pellegrino, M, Chang, YT, Mazzolai, B, Mattoli, V, Suzuki, M & Ciofani, G 2015, 'Piezoelectric Nanoparticle-Assisted Wireless Neuronal Stimulation', ACS Nano, vol. 9, no. 7, pp. 7678-7689. https://doi.org/10.1021/acsnano.5b03162
Marino A, Arai S, Hou Y, Sinibaldi E, Pellegrino M, Chang YT et al. Piezoelectric Nanoparticle-Assisted Wireless Neuronal Stimulation. ACS Nano. 2015 Jul 28;9(7):7678-7689. https://doi.org/10.1021/acsnano.5b03162
Marino, Attilio ; Arai, Satoshi ; Hou, Yanyan ; Sinibaldi, Edoardo ; Pellegrino, Mario ; Chang, Young Tae ; Mazzolai, Barbara ; Mattoli, Virgilio ; Suzuki, Madoka ; Ciofani, Gianni. / Piezoelectric Nanoparticle-Assisted Wireless Neuronal Stimulation. In: ACS Nano. 2015 ; Vol. 9, No. 7. pp. 7678-7689.
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