Pinacolyl methyl phosphonate (PMP) detection by molecularly imprinted polymers (MIP): A labile covalent bonding approach

Prasad Taranekar, Chengyu Huang, Rigoberto C. Advincula

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)

Abstract

Molecularly imprinted polymers (MIP) have become increasingly important in the area of separation and detection. They are emerging tools for the design of structured porous materials having a precise arrangement of functional groups within pores of controlled size and shape. In the present study, covalent molecular imprinting was achieved by using styrene and di-acrylate monomers together with covalently tethered nerve agent (NA) analogs. Due to the nonpersistent nature of this class of nerve agents, the covalent attachment ensures the integrity of the analyte as opposed to a non-covalent approach where the decomposition products of pinacolyl methyl phosphonate (PMP) can lead to a variety of binding cavities based upon the nature of the decomposed products. The binding affinity of the imprinted polymers to the NA analogs, as studied by colorimetric methods, was found to be efficient and highly selective.{A figure is presented}.

Original languageEnglish
Pages (from-to)6485-6490
Number of pages6
JournalPolymer
Volume47
Issue number19
DOIs
Publication statusPublished - 2006 Sep 7
Externally publishedYes

Keywords

  • Covalent bonding
  • Molecular imprinting
  • Pinacolyl methyl phosphonate

ASJC Scopus subject areas

  • Polymers and Plastics
  • Organic Chemistry

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