Point-to-Point Ultra-Remote Asymmetric Control with Flexible Linker

Tsuneomi Kawasaki, Yasuyuki Ishikawa, Yoshihiro Minato, Takashi Otsuka, Shigeru Yonekubo, Itaru Sato, Takanori Shibata, Arimasa Matsumoto, Kenso Soai

    Research output: Contribution to journalArticle

    5 Citations (Scopus)

    Abstract

    An ultra-remote intramolecular (point-to-point) asymmetric control through 38 bonds (1,39-asymmetric induction) has been achieved by using the principle of direct supramolecular orientation of catalytic and reactive moieties in asymmetric autocatalysis. We found the highly stereoselective diisopropylzinc addition reaction using designed molecules possessing pyrimidine sites at each terminal of a conformationally flexible simple methylene chain.

    Original languageEnglish
    Pages (from-to)282-285
    Number of pages4
    JournalChemistry - A European Journal
    Volume23
    Issue number2
    DOIs
    Publication statusPublished - 2017 Jan 5

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    Keywords

    • 5-pyrimidyl alkanol
    • asymmetric amplification
    • intramolecular stereocontrol
    • remote asymmetric induction
    • stereoselective reaction

    ASJC Scopus subject areas

    • Chemistry(all)

    Cite this

    Kawasaki, T., Ishikawa, Y., Minato, Y., Otsuka, T., Yonekubo, S., Sato, I., Shibata, T., Matsumoto, A., & Soai, K. (2017). Point-to-Point Ultra-Remote Asymmetric Control with Flexible Linker. Chemistry - A European Journal, 23(2), 282-285. https://doi.org/10.1002/chem.201605076