Point-to-Point Ultra-Remote Asymmetric Control with Flexible Linker

Tsuneomi Kawasaki, Yasuyuki Ishikawa, Yoshihiro Minato, Takashi Otsuka, Shigeru Yonekubo, Itaru Sato, Takanori Shibata, Arimasa Matsumoto, Kenso Soai

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

An ultra-remote intramolecular (point-to-point) asymmetric control through 38 bonds (1,39-asymmetric induction) has been achieved by using the principle of direct supramolecular orientation of catalytic and reactive moieties in asymmetric autocatalysis. We found the highly stereoselective diisopropylzinc addition reaction using designed molecules possessing pyrimidine sites at each terminal of a conformationally flexible simple methylene chain.

Original languageEnglish
Pages (from-to)282-285
Number of pages4
JournalChemistry - A European Journal
Volume23
Issue number2
DOIs
Publication statusPublished - 2017

Keywords

  • 5-pyrimidyl alkanol
  • asymmetric amplification
  • intramolecular stereocontrol
  • remote asymmetric induction
  • stereoselective reaction

ASJC Scopus subject areas

  • Catalysis
  • Organic Chemistry

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  • Cite this

    Kawasaki, T., Ishikawa, Y., Minato, Y., Otsuka, T., Yonekubo, S., Sato, I., Shibata, T., Matsumoto, A., & Soai, K. (2017). Point-to-Point Ultra-Remote Asymmetric Control with Flexible Linker. Chemistry - A European Journal, 23(2), 282-285. https://doi.org/10.1002/chem.201605076