Polo-like kinase Cdc5 controls the local activation of Rho1 to promote cytokinesis

Satoshi Yoshida, Keiko Kono, Drew M. Lowery, Sara Bartolini, Michael B. Yaffe, Yoshikazu Ohya, David Pellman*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

122 Citations (Scopus)


The links between the cell cycle machinery and the cytoskeletal proteins controlling cytokinesis are poorly understood. The small guanine nucleotide triphosphate (GTP)-binding protein RhoA stimulates type II myosin contractility and formin-dependent assembly of the cytokinetic actin contractile ring. We found that budding yeast Polo-like kinase Cdc5 controls the targeting and activation of Rho1 (RhoA) at the division site via Rho1 guanine nucleotide exchange factors. This role of Cdc5 (Polo-like kinase) in regulating Rho1 is likely to be relevant to cytokinesis and asymmetric cell division in other organisms.

Original languageEnglish
Pages (from-to)108-111
Number of pages4
Issue number5783
Publication statusPublished - 2006 Jul 7
Externally publishedYes

ASJC Scopus subject areas

  • General


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