Abstract
The links between the cell cycle machinery and the cytoskeletal proteins controlling cytokinesis are poorly understood. The small guanine nucleotide triphosphate (GTP)-binding protein RhoA stimulates type II myosin contractility and formin-dependent assembly of the cytokinetic actin contractile ring. We found that budding yeast Polo-like kinase Cdc5 controls the targeting and activation of Rho1 (RhoA) at the division site via Rho1 guanine nucleotide exchange factors. This role of Cdc5 (Polo-like kinase) in regulating Rho1 is likely to be relevant to cytokinesis and asymmetric cell division in other organisms.
Original language | English |
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Pages (from-to) | 108-111 |
Number of pages | 4 |
Journal | Science |
Volume | 313 |
Issue number | 5783 |
DOIs | |
Publication status | Published - 2006 Jul 7 |
Externally published | Yes |
ASJC Scopus subject areas
- General