Abstract
The links between the cell cycle machinery and the cytoskeletal proteins controlling cytokinesis are poorly understood. The small guanine nucleotide triphosphate (GTP)-binding protein RhoA stimulates type II myosin contractility and formin-dependent assembly of the cytokinetic actin contractile ring. We found that budding yeast Polo-like kinase Cdc5 controls the targeting and activation of Rho1 (RhoA) at the division site via Rho1 guanine nucleotide exchange factors. This role of Cdc5 (Polo-like kinase) in regulating Rho1 is likely to be relevant to cytokinesis and asymmetric cell division in other organisms.
| Original language | English |
|---|---|
| Pages (from-to) | 108-111 |
| Number of pages | 4 |
| Journal | Science |
| Volume | 313 |
| Issue number | 5783 |
| DOIs | |
| Publication status | Published - 2006 Jul 7 |
ASJC Scopus subject areas
- General
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Yoshida, S., Kono, K., Lowery, D. M., Bartolini, S., Yaffe, M. B., Ohya, Y., & Pellman, D. (2006). Polo-like kinase Cdc5 controls the local activation of Rho1 to promote cytokinesis. Science, 313(5783), 108-111. https://doi.org/10.1126/science.1126747