Polo-like kinase Cdc5 controls the local activation of Rho1 to promote cytokinesis

Satoshi Yoshida, Keiko Kono, Drew M. Lowery, Sara Bartolini, Michael B. Yaffe, Yoshikazu Ohya, David Pellman

Research output: Contribution to journalArticle

113 Citations (Scopus)

Abstract

The links between the cell cycle machinery and the cytoskeletal proteins controlling cytokinesis are poorly understood. The small guanine nucleotide triphosphate (GTP)-binding protein RhoA stimulates type II myosin contractility and formin-dependent assembly of the cytokinetic actin contractile ring. We found that budding yeast Polo-like kinase Cdc5 controls the targeting and activation of Rho1 (RhoA) at the division site via Rho1 guanine nucleotide exchange factors. This role of Cdc5 (Polo-like kinase) in regulating Rho1 is likely to be relevant to cytokinesis and asymmetric cell division in other organisms.

Original languageEnglish
Pages (from-to)108-111
Number of pages4
JournalScience
Volume313
Issue number5783
DOIs
Publication statusPublished - 2006 Jul 7
Externally publishedYes

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Cytokinesis
Phosphotransferases
Asymmetric Cell Division
Myosin Type II
Guanine Nucleotide Exchange Factors
Saccharomycetales
Cytoskeletal Proteins
Guanine Nucleotides
Actins
Cell Cycle
Carrier Proteins
triphosphoric acid

ASJC Scopus subject areas

  • General

Cite this

Yoshida, S., Kono, K., Lowery, D. M., Bartolini, S., Yaffe, M. B., Ohya, Y., & Pellman, D. (2006). Polo-like kinase Cdc5 controls the local activation of Rho1 to promote cytokinesis. Science, 313(5783), 108-111. https://doi.org/10.1126/science.1126747

Polo-like kinase Cdc5 controls the local activation of Rho1 to promote cytokinesis. / Yoshida, Satoshi; Kono, Keiko; Lowery, Drew M.; Bartolini, Sara; Yaffe, Michael B.; Ohya, Yoshikazu; Pellman, David.

In: Science, Vol. 313, No. 5783, 07.07.2006, p. 108-111.

Research output: Contribution to journalArticle

Yoshida, S, Kono, K, Lowery, DM, Bartolini, S, Yaffe, MB, Ohya, Y & Pellman, D 2006, 'Polo-like kinase Cdc5 controls the local activation of Rho1 to promote cytokinesis', Science, vol. 313, no. 5783, pp. 108-111. https://doi.org/10.1126/science.1126747
Yoshida S, Kono K, Lowery DM, Bartolini S, Yaffe MB, Ohya Y et al. Polo-like kinase Cdc5 controls the local activation of Rho1 to promote cytokinesis. Science. 2006 Jul 7;313(5783):108-111. https://doi.org/10.1126/science.1126747
Yoshida, Satoshi ; Kono, Keiko ; Lowery, Drew M. ; Bartolini, Sara ; Yaffe, Michael B. ; Ohya, Yoshikazu ; Pellman, David. / Polo-like kinase Cdc5 controls the local activation of Rho1 to promote cytokinesis. In: Science. 2006 ; Vol. 313, No. 5783. pp. 108-111.
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