Polo-like kinase Cdc5 controls the local activation of Rho1 to promote cytokinesis

Satoshi Yoshida, Keiko Kono, Drew M. Lowery, Sara Bartolini, Michael B. Yaffe, Yoshikazu Ohya, David Pellman

Research output: Contribution to journalArticle

115 Citations (Scopus)

Abstract

The links between the cell cycle machinery and the cytoskeletal proteins controlling cytokinesis are poorly understood. The small guanine nucleotide triphosphate (GTP)-binding protein RhoA stimulates type II myosin contractility and formin-dependent assembly of the cytokinetic actin contractile ring. We found that budding yeast Polo-like kinase Cdc5 controls the targeting and activation of Rho1 (RhoA) at the division site via Rho1 guanine nucleotide exchange factors. This role of Cdc5 (Polo-like kinase) in regulating Rho1 is likely to be relevant to cytokinesis and asymmetric cell division in other organisms.

Original languageEnglish
Pages (from-to)108-111
Number of pages4
JournalScience
Volume313
Issue number5783
DOIs
Publication statusPublished - 2006 Jul 7

ASJC Scopus subject areas

  • General

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    Yoshida, S., Kono, K., Lowery, D. M., Bartolini, S., Yaffe, M. B., Ohya, Y., & Pellman, D. (2006). Polo-like kinase Cdc5 controls the local activation of Rho1 to promote cytokinesis. Science, 313(5783), 108-111. https://doi.org/10.1126/science.1126747