Polyadenylation in mammalian mitochondria: Insights from recent studies

Takashi Nagaike, Tsutomu Suzuki, Takuya Ueda

Research output: Contribution to journalReview article

29 Citations (Scopus)


Polyadenylation in animal mitochondria is very unique. Unlike other systems, polyadenylation is needed to generate UAA stop codons that are not encoded in mitochondrial (mt) DNA. In some cases, polyadenylation is required for the mt tRNA maturation by editing of its 3′ termini. Furthermore, recent studies on human mt poly(A) polymerase (PAP) and PNPase provide new insights and questions for the regulatory mechanism and functional role of polyadenylation in human mitochondria.

Original languageEnglish
Pages (from-to)266-269
Number of pages4
JournalBiochimica et Biophysica Acta - Gene Regulatory Mechanisms
Issue number4
Publication statusPublished - 2008 Apr 1



  • Mitochondrial
  • Poly(A) polymerase
  • Polyadenylation
  • mRNA stability

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics

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