Polyadenylation in mammalian mitochondria: Insights from recent studies

Takashi Nagaike; Tsutomu Suzuki; Takuya Ueda

doi:10.1016/j.bbagrm.2008.02.001

Polyadenylation in mammalian mitochondria: Insights from recent studies

Takashi Nagaike, Tsutomu Suzuki, Takuya Ueda^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

33 Citations (Scopus)

Abstract

Polyadenylation in animal mitochondria is very unique. Unlike other systems, polyadenylation is needed to generate UAA stop codons that are not encoded in mitochondrial (mt) DNA. In some cases, polyadenylation is required for the mt tRNA maturation by editing of its 3′ termini. Furthermore, recent studies on human mt poly(A) polymerase (PAP) and PNPase provide new insights and questions for the regulatory mechanism and functional role of polyadenylation in human mitochondria.

Original language	English
Pages (from-to)	266-269
Number of pages	4
Journal	Biochimica et Biophysica Acta - Gene Regulatory Mechanisms
Volume	1779
Issue number	4
DOIs	https://doi.org/10.1016/j.bbagrm.2008.02.001
Publication status	Published - 2008 Apr
Externally published	Yes

Keywords

Mitochondrial
Poly(A) polymerase
Polyadenylation
mRNA stability

ASJC Scopus subject areas

Biophysics
Structural Biology
Biochemistry
Molecular Biology
Genetics

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10.1016/j.bbagrm.2008.02.001

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abstract = "Polyadenylation in animal mitochondria is very unique. Unlike other systems, polyadenylation is needed to generate UAA stop codons that are not encoded in mitochondrial (mt) DNA. In some cases, polyadenylation is required for the mt tRNA maturation by editing of its 3′ termini. Furthermore, recent studies on human mt poly(A) polymerase (PAP) and PNPase provide new insights and questions for the regulatory mechanism and functional role of polyadenylation in human mitochondria.",

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journal = "Biochimica et Biophysica Acta - Gene Regulatory Mechanisms",

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T2 - Insights from recent studies

AU - Nagaike, Takashi

AU - Suzuki, Tsutomu

AU - Ueda, Takuya

PY - 2008/4

Y1 - 2008/4

N2 - Polyadenylation in animal mitochondria is very unique. Unlike other systems, polyadenylation is needed to generate UAA stop codons that are not encoded in mitochondrial (mt) DNA. In some cases, polyadenylation is required for the mt tRNA maturation by editing of its 3′ termini. Furthermore, recent studies on human mt poly(A) polymerase (PAP) and PNPase provide new insights and questions for the regulatory mechanism and functional role of polyadenylation in human mitochondria.

AB - Polyadenylation in animal mitochondria is very unique. Unlike other systems, polyadenylation is needed to generate UAA stop codons that are not encoded in mitochondrial (mt) DNA. In some cases, polyadenylation is required for the mt tRNA maturation by editing of its 3′ termini. Furthermore, recent studies on human mt poly(A) polymerase (PAP) and PNPase provide new insights and questions for the regulatory mechanism and functional role of polyadenylation in human mitochondria.

KW - Mitochondrial

KW - Poly(A) polymerase

KW - Polyadenylation

KW - mRNA stability

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U2 - 10.1016/j.bbagrm.2008.02.001

DO - 10.1016/j.bbagrm.2008.02.001

M3 - Review article

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AN - SCOPUS:41549094036

SN - 1874-9399

VL - 1779

SP - 266

EP - 269

JO - Biochimica et Biophysica Acta - Gene Regulatory Mechanisms

JF - Biochimica et Biophysica Acta - Gene Regulatory Mechanisms

IS - 4

ER -

Polyadenylation in mammalian mitochondria: Insights from recent studies

Abstract

Keywords

ASJC Scopus subject areas

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