Abstract
The left-right (LR) axis is essential for the proper function of internal organs. In mammals and fish, left-sided Nodal expression governs LR patterning. Here, we show that the Polycomb group protein Ezh1, which is highly conserved from fish to human, participates in LR patterning. Knockdown of olezh1, a medaka homologue of Ezh1, led to LR reversal of internal organs. It was shown that OLEZH1 acts in silencing the expression of Spaw (a medaka homolog of Nodal) via a previously unknown pathway. Furthermore, coimmunoprecipitation showed physical interaction of Ezh1 with FoxH1, a Nodal regulator. This represents a novel mechanism for LR patterning and implies that Ezh1 has developmental importance.
| Original language | English |
|---|---|
| Pages (from-to) | 459-463 |
| Number of pages | 5 |
| Journal | Developmental Biology |
| Volume | 341 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2010 May |
Keywords
- Ezh1
- Left-right axis
- Medaka
- Nodal
- Polycomb
ASJC Scopus subject areas
- Molecular Biology
- Developmental Biology
- Cell Biology
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Arai, D., Katsura, H., Shindo, N., Matsumoto, M., & Higashinakagawa, T. (2010). Polycomb group protein Ezh1 represses Nodal and maintains the left-right axis. Developmental Biology, 341(2), 459-463. https://doi.org/10.1016/j.ydbio.2010.03.002