Polycomb group protein Ezh1 represses Nodal and maintains the left-right axis

Daisuke Arai, Hiroaki Katsura, Norihisa Shindo, Mayuko Matsumoto, Toru Higashinakagawa

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The left-right (LR) axis is essential for the proper function of internal organs. In mammals and fish, left-sided Nodal expression governs LR patterning. Here, we show that the Polycomb group protein Ezh1, which is highly conserved from fish to human, participates in LR patterning. Knockdown of olezh1, a medaka homologue of Ezh1, led to LR reversal of internal organs. It was shown that OLEZH1 acts in silencing the expression of Spaw (a medaka homolog of Nodal) via a previously unknown pathway. Furthermore, coimmunoprecipitation showed physical interaction of Ezh1 with FoxH1, a Nodal regulator. This represents a novel mechanism for LR patterning and implies that Ezh1 has developmental importance.

Original languageEnglish
Pages (from-to)459-463
Number of pages5
JournalDevelopmental Biology
Volume341
Issue number2
DOIs
Publication statusPublished - 2010 May

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Keywords

  • Ezh1
  • Left-right axis
  • Medaka
  • Nodal
  • Polycomb

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology
  • Molecular Biology

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