Polymerization liposome/lipid-heme as an oxygen transporter under physiological conditions

Eishun Tsuchida, Hiroyuki Nishide, Makoto Yuasa, Etsuo Hasegawa, Kiyoshi Eshima, Yoh ichi Matsushita

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Copolymerized liposome of 1,2-bis(octadeca-2′,4′-dienoyl)-sn-glycero-3-phosphocholine and sodium 15-(1′-imidazolyl)pentadeca-trans-2,trans-4-dienoate is an effective carrier of [5α,10α,15α,20α-tetrakis [ο-[2′, 2′-dimethyl-20′-[2″-(trimethylammonio)ethyl] phosphonatoxyeicosanamido] phenyl] porphinato] iron(II) (lipid-heme): This polymerized liposome/lipid-heme transports molecular oxygen under physiological conditions (in pH 7, at 37°C). The lipid-heme is embedded and fixed in the bilayer of polymerized liposome based on hydrophilic-hydrophobic balance of the lipid-heme and/or coordination bond between the lipid-heme and the copolymerized imidazole residue. Solution properties of the polymerized liposome/lipid-heme are almost the same as those of human blood, and the solution is able to be stocked for months. Oxygen volume dissolved in the polymerized liposome/lipid-heme solution (100 mL) is determined to be ca. 22 mL by an 15O radiotracer method and by volumetry, which is comparable with that of human blood. Oxygen-binding affinity and rate constant of the polymerized liposome/lipid-heme are ca. 50 mmHg and 104M-1s-1, respectively, which are also similar to those of hemoglobin in blood.

Original languageEnglish
Pages (from-to)2103-2107
Number of pages5
JournalMacromolecules
Volume22
Issue number5
Publication statusPublished - 1989 May

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Liposomes
Heme
Lipids
Polymerization
Oxygen
Blood
Phosphorylcholine
Molecular oxygen
Hemoglobin
Rate constants
Hemoglobins
Iron
Sodium

ASJC Scopus subject areas

  • Materials Chemistry

Cite this

Tsuchida, E., Nishide, H., Yuasa, M., Hasegawa, E., Eshima, K., & Matsushita, Y. I. (1989). Polymerization liposome/lipid-heme as an oxygen transporter under physiological conditions. Macromolecules, 22(5), 2103-2107.

Polymerization liposome/lipid-heme as an oxygen transporter under physiological conditions. / Tsuchida, Eishun; Nishide, Hiroyuki; Yuasa, Makoto; Hasegawa, Etsuo; Eshima, Kiyoshi; Matsushita, Yoh ichi.

In: Macromolecules, Vol. 22, No. 5, 05.1989, p. 2103-2107.

Research output: Contribution to journalArticle

Tsuchida, E, Nishide, H, Yuasa, M, Hasegawa, E, Eshima, K & Matsushita, YI 1989, 'Polymerization liposome/lipid-heme as an oxygen transporter under physiological conditions', Macromolecules, vol. 22, no. 5, pp. 2103-2107.
Tsuchida E, Nishide H, Yuasa M, Hasegawa E, Eshima K, Matsushita YI. Polymerization liposome/lipid-heme as an oxygen transporter under physiological conditions. Macromolecules. 1989 May;22(5):2103-2107.
Tsuchida, Eishun ; Nishide, Hiroyuki ; Yuasa, Makoto ; Hasegawa, Etsuo ; Eshima, Kiyoshi ; Matsushita, Yoh ichi. / Polymerization liposome/lipid-heme as an oxygen transporter under physiological conditions. In: Macromolecules. 1989 ; Vol. 22, No. 5. pp. 2103-2107.
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